Save up -80% on Conivaptan
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2018 Price of Conivaptan
Vaprisol 20 mg/100 ml bag
* price without discount in nearest pharmacy. Price may vary.
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Conivaptan volume of distribution
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Conivaptan
Conivaptan is a non-peptide inhibitor of antidiuretic hormone (vasopressin). It was approved in 2004 for hyponatremia (low blood sodium levels) caused by syndrome of inappropriate antidiuretic hormone (SIADH). Conivaptan inhibits both isotypes of the vasopressin receptor (V1a and V2).
Conivaptan mechanism of action
Conivaptan is a dual AVP antagonist with nanomolar affinity for human arginine vasopressin Vsub1A/sub and Vsub2/sub receptors iin vitro/i. This antagonism occurs in the renal collecting ducts, resulting in aquaresis, or excretion of free water.
Dosage forms of Conivaptan
|Injection, solution||intravenous||20 mg/100mL|
Vaprisol Dextrose In Plastic Container
Cumberland Pharmaceuticals Inc.
Humans and other mammals
Indication of Conivaptan
For the treatment of euvolemic or hypervolemic hyponatremia (e.g. the syndrome of inappropriate secretion of antidiuretic hormone, or in the setting of hypothyroidism, adrenal insufficiency, pulmonary disorders, etc.) in hospitalized patients.
Toxicity of Conivaptan
Although no data on overdosage in humans are available, conivaptan has been administered as a 20 mg loading dose on Day 1 followed by continuous infusion of 80 mg/day for 4 days in hyponatremia patients and up to 120 mg/day for 2 days in CHF patients. No new toxicities were identified at these higher doses, but adverse events related to the pharmacologic activity of conivaptan, e.g. hypotension and thirst, occurred more frequently at these higher doses.
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