Save up -80% on Cosyntropin
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2018 Price of Cosyntropin
Synacthen Depot 1 mg/vial
* price without discount in nearest pharmacy. Price may vary.
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Cosyntropin volume of distribution
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Cosyntropin
A synthetic peptide that is identical to the 24-amino acid segment at the N-terminal of adrenocorticotropic hormone. ACTH (1-24), a segment similar in all species, contains the biological activity that stimulates production of corticosteroids in the adrenal cortex.
Cosyntropin mechanism of action
Cosyntropin combines with a specific receptor in the adrenal cell plasma membrane and, in patients with normal adrenocortical function, stimulates the initial reaction involved in the synthesis of adrenal steroids (including cortisol, cortisone, weak androgenic substances, and a limited quantity of aldosterone) from cholesterol by increasing the quantity of the substrate within the mitochondria. Cosyntropin does not significantly increase plasma cortisol concentration in patients with primary or secondary adrenocortical insufficiency.
Dosage forms of Cosyntropin
|Injection, powder, for solution||intramuscular; intravenous; parenteral||.25 mg/mL|
|Injection, powder, lyophilized, for solution||intramuscular; intravenous||.25 mg/mL|
|Powder for solution||intramuscular; intravenous||0.25 mg|
Adrenocorticotropic hormone 1-24 alpha(1-24)-Corticotrophin
General Injectables – Vaccines, Inc
Humans and other mammals
Indication of Cosyntropin
For use as a diagnostic agent in the screening of patients presumed to have adrenocortical insufficiency.
Toxicity of Cosyntropin
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