Save up -80% on Crizotinib

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RX BIN: 015558RX PCN: HTGroup ID: DDN6600Card Holder ID: DDN6600
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2019 Price of Xalkori

$17,062.9160 capsules/250 mg
price without discount in nearest pharmacy. Price may vary.

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Crizotinib volume of distribution

Mean volume of distribution (Vss) is 1772 L following intravenous administration of a 50 mg dose. This high volume of distribution suggest extensive distribution into tissue from plasma.

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2018 Statistics

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Discount Cards 16,000+


Clients Benefit 29%


Total savings $4,735,080

What is Crizotinib

Crizotinib an inhibitor of receptor tyrosine kinase for the treatment of non-small cell lung cancer (NSCLC). Verification of the presence of ALK fusion gene is done by Abbott Molecular’s Vysis ALK Break Apart FISH Probe Kit. This verification is used to select for patients suitable for treatment. FDA approved in August 26, 2011.

Crizotinib mechanism of action

Crizotinib is a tyrosine kinase receptor inhibitor. More specifically, it inhibits anaplastic lymphoma kinase (ALK), hepatocyte growth factor receptor (HGFR, c-MET), and Recepteur d’Origine Nantais (RON). Abnormalities in the ALK gene caused by mutations or translocations may lead to expression of oncogenic fusion proteins. In patients with NSCLC, they have the EML4-ALK gene. Crizotinib inhibits ALK tyrosine kinase which ultimately results in decreased proliferation of cells that carry the genetic mutation and tumour survivability.

Dosage forms of Crizotinib

Capsuleoral200 mg
Capsuleoral200 mg/1
Capsuleoral250 mg

Prescription Generics


International Brands



(R)-Crizotinib C-Met/Hepatocyte Growth Factor Receptor Tyrosine Kinase Inhibitor PF-02341066


Pfizer Laboratories Div Pfizer Inc

CAS number






Affected organisms

Humans and other mammals

Indication of Crizotinib

Crizotinib is used for the treatment of locally advanced or metastatic non-small cell lung cancer (NSCLC) that is anaplastic-lymphoma kinase (ALK)-positive as detected by a FDA-approved test.

Toxicity of Crizotinib

Pulmonary toxicity from crizotinib is a rare, but potentially life-threatening, adverse reaction. This rare toxicity has been seen with other small-molecule tyrosine kinase inhibitors, including gefitinib and erlotinib. In profile 1001 and 1005, severe pneumonitis was seen in 1.6% (4 of 255) of patients16. Typically, the event happened within 2 months after initiation of treatment. Cases of fatal crizotinib-induced pneumonitis have occurred 27.

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