Save up -80% on Crofelemer

Note: this is a drug discount program, not an insurance plan.
RX BIN: 015558RX PCN: HTGroup ID: DDN6600Card Holder ID: DDN6600
Pharmacists and Patients support.

2019 Price of Mytesi

$30330 tablets/125 mg
price without discount in nearest pharmacy. Price may vary.

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We offer free Crofelemer coupons and discounts that may help you save up to 80% off the retail price in your local pharmacy. Just print your coupon! It’s ready to use and never expire. Present your manufacturer copay card in most local pharmacies to get a discount on Crofelemer every time. What are you waiting for? Claim your prescription drug card now!

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Crofelemer volume of distribution

Since crofelemer is not significantly absorbed, volume of distribution was not quantified.

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About RX24Drugs

2018 Statistics

discount card

Discount Cards 16,000+


Clients Benefit 29%


Total savings $4,735,080

What is Crofelemer

Crofelemer, previously known as the investigational drug SP-303, is a novel proanthocyanidin purified from the bark latex of the Amazonian Croton tree iCroton lechleri/i. It is marketed under the brand name Fulyzaq and indicated for the symptomatic treatment of non-infectious diarrhea in adult patients with HIV/AIDS who are taking antiretroviral therapy.

Crofelemer mechanism of action

Crofelemer is an inhibitor of the cystic fibrosis transmembrane regulator chloride channel (CFTR), as evidenced by its activity on cell cultures, single cell patch clamps, single CFTR channels, and elaboration of mouse intestinal fluid secretion. Crofelemer also inhibits calcium activated chloride channels (CaCC), which in combination with CFTR, are expressed on the luminal side of intestinal cells. Crofelemer inhibition of both of these channels prevents water loss from diarrhea by inhibiting chloride secretion.

Dosage forms of Crofelemer

Tablet, coatedoral125 mg/1

Prescription Generics


International Brands



Provir SP-303


Salix Pharmaceuticals, Inc.

CAS number






Affected organisms

Humans and other mammals

Indication of Crofelemer

For the symptomatic treatment of non-infectious diarrhea in adult patients with HIV/AIDS who are taking antiretroviral therapy.

Toxicity of Crofelemer

The most common adverse effects are cough, flatulence, upper respiratory tract infection, bronchitis, and increased bilirubin.

RX24 Drugs Disclaimer: consult your healthcare provider before buying a Crofelemer on prescription or using an RX manufacturer savings coupon. Content on this page is provided for informational purposes only. Any use of this information is at your own risk.

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