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RX BIN: 015558
Group ID: DDN6600
Card Holder ID: DDN6600

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2018 Price of Crofelemer


* price without discount in nearest pharmacy. Price may vary.

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Crofelemer volume of distribution

Since crofelemer is not significantly absorbed, volume of distribution was not quantified.

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What is Crofelemer

Crofelemer, previously known as the investigational drug SP-303, is a novel proanthocyanidin purified from the bark latex of the Amazonian Croton tree iCroton lechleri/i. It is marketed under the brand name Fulyzaq and indicated for the symptomatic treatment of non-infectious diarrhea in adult patients with HIV/AIDS who are taking antiretroviral therapy.

Crofelemer mechanism of action

Crofelemer is an inhibitor of the cystic fibrosis transmembrane regulator chloride channel (CFTR), as evidenced by its activity on cell cultures, single cell patch clamps, single CFTR channels, and elaboration of mouse intestinal fluid secretion. Crofelemer also inhibits calcium activated chloride channels (CaCC), which in combination with CFTR, are expressed on the luminal side of intestinal cells. Crofelemer inhibition of both of these channels prevents water loss from diarrhea by inhibiting chloride secretion.

Dosage forms of Crofelemer

Tablet, coatedoral125 mg/1
Prescription Generics


International Brands



Provir SP-303


Salix Pharmaceuticals, Inc.

CAS number






Affected organisms

Humans and other mammals

Indication of Crofelemer

For the symptomatic treatment of non-infectious diarrhea in adult patients with HIV/AIDS who are taking antiretroviral therapy.

Toxicity of Crofelemer

The most common adverse effects are cough, flatulence, upper respiratory tract infection, bronchitis, and increased bilirubin.

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