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2018 Price of Crofelemer
* price without discount in nearest pharmacy. Price may vary.
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Crofelemer volume of distribution
Since crofelemer is not significantly absorbed, volume of distribution was not quantified.
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Crofelemer
Crofelemer, previously known as the investigational drug SP-303, is a novel proanthocyanidin purified from the bark latex of the Amazonian Croton tree iCroton lechleri/i. It is marketed under the brand name Fulyzaq and indicated for the symptomatic treatment of non-infectious diarrhea in adult patients with HIV/AIDS who are taking antiretroviral therapy.
Crofelemer mechanism of action
Crofelemer is an inhibitor of the cystic fibrosis transmembrane regulator chloride channel (CFTR), as evidenced by its activity on cell cultures, single cell patch clamps, single CFTR channels, and elaboration of mouse intestinal fluid secretion. Crofelemer also inhibits calcium activated chloride channels (CaCC), which in combination with CFTR, are expressed on the luminal side of intestinal cells. Crofelemer inhibition of both of these channels prevents water loss from diarrhea by inhibiting chloride secretion.
Dosage forms of Crofelemer
|Tablet, coated||oral||125 mg/1|
Salix Pharmaceuticals, Inc.
Humans and other mammals
Indication of Crofelemer
For the symptomatic treatment of non-infectious diarrhea in adult patients with HIV/AIDS who are taking antiretroviral therapy.
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