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RX BIN: 015558
Group ID: DDN6600
Card Holder ID: DDN6600

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2018 Price of Cyclosporine

Gengraf 25 mg capsule



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Cyclosporine volume of distribution

The steady state volume of distribution during intravenous dosing has been reported as 3 to 5 L/kg in solid organ transplant recipients. Cyclosporine is excreted in human milk.

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What is Cyclosporine

A cyclic undecapeptide from an extract of soil fungi. It is a powerful immunosupressant with a specific action on T-lymphocytes. It is used for the prophylaxis of graft rejection in organ and tissue transplantation. Cyclosporine is produced as a metabolite by the fungus species Cordyceps militaris. (From Martindale, The Extra Pharmacopoeia, 30th ed).

Cyclosporine mechanism of action

Cyclosporine binds to cyclophilin. The complex then inhibits calcineurin which is normally responsible for activating transcription of interleukin 2. Cyclosporine also inhibits lymphokine production and interleukin release. In ophthalmic applications, the precise mechanism of action is not known. Cyclosporine emulsion is thought to act as a partial immunomodulator in patients whose tear production is presumed to be suppressed due to ocular inflammation associated with keratoconjunctivitis sicca.

Dosage forms of Cyclosporine

Form Route Strength
Capsule oral 100 mg/1
Capsule oral 25 mg/1
Capsule, gelatin coated oral 100 mg/1
Prescription Generics


International Brands

Apo-cyclosporine Oral Solution


Ciclosporin Ciclosporina


Apotex Inc

CAS number






Affected organisms

Humans and other mammals

Indication of Cyclosporine

For treatment of transplant (kidney, liver, and heart) rejection, rheumatoid arthritis, severe psoriasis.

Toxicity of Cyclosporine

The oral LD sub 50 /sub is 2329 mg/kg in mice, 1480 mg/kg in rats, and 1000 mg/kg in rabbits. The I.V. LD sub 50 /sub is 148 mg/kg in mice, 104 mg/kg in rats, and 46 mg/kg in rabbits.

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