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RX BIN: 015558
Group ID: DDN6600
Card Holder ID: DDN6600

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2018 Price of Cyclosporine

Gengraf 25 mg capsule



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Cyclosporine volume of distribution

The steady state volume of distribution during intravenous dosing has been reported as 3 to 5 L/kg in solid organ transplant recipients. Cyclosporine is excreted in human milk.

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What is Cyclosporine

A cyclic undecapeptide from an extract of soil fungi. It is a powerful immunosupressant with a specific action on T-lymphocytes. It is used for the prophylaxis of graft rejection in organ and tissue transplantation. Cyclosporine is produced as a metabolite by the fungus species Cordyceps militaris. (From Martindale, The Extra Pharmacopoeia, 30th ed).

Cyclosporine mechanism of action

Cyclosporine binds to cyclophilin. The complex then inhibits calcineurin which is normally responsible for activating transcription of interleukin 2. Cyclosporine also inhibits lymphokine production and interleukin release. In ophthalmic applications, the precise mechanism of action is not known. Cyclosporine emulsion is thought to act as a partial immunomodulator in patients whose tear production is presumed to be suppressed due to ocular inflammation associated with keratoconjunctivitis sicca.

Dosage forms of Cyclosporine

Neoral10mg60 Capsule$85.00
Neoral25mg50 Capsule$110.00
Neoral50mg30 Capsule$129.00
Neoral100mg50 Capsule$200.00
Neoral Oral Solution100mg/mL50mL Reconstitution Suspension$240.00
Cyclosporine25mg30 Capsule$40.00
Cyclosporine50mg60 Capsule$121.00
Cyclosporine100mg90 Capsule$287.00
Cyclosporine0.05%3mL Eye drops$32.00
Cyclosporine0.05%9mL Eye drops$74.00
Atopica25mg15 Capsule$49.00
Atopica25mg30 Capsule$85.00
Restasis0.05%30vials Vials (Eye Drops)$51.65
Restasis0.05%90vials Vials (Eye Drops)$171.00
Prescription Generics


International Brands

Apo-cyclosporine Oral Solution


Ciclosporin Ciclosporina


Apotex Inc

CAS number






Affected organisms

Humans and other mammals

Indication of Cyclosporine

For treatment of transplant (kidney, liver, and heart) rejection, rheumatoid arthritis, severe psoriasis.

Toxicity of Cyclosporine

The oral LD sub 50 /sub is 2329 mg/kg in mice, 1480 mg/kg in rats, and 1000 mg/kg in rabbits. The I.V. LD sub 50 /sub is 148 mg/kg in mice, 104 mg/kg in rats, and 46 mg/kg in rabbits.

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