Save up -80% on Cyclosporine
|Note: this is a drug discount program, not an insurance plan.|
|RX BIN: 015558||RX PCN: HT||Group ID: DDN6600||Card Holder ID: DDN6600|
|Pharmacists and Patients support.|
2019 Price of Restasis
|$572.93||1 package (60 vials) 0.4 ml|
|price without discount in nearest pharmacy. Price may vary.|
We offer free Restasis coupons and discounts that may help you save up to 80% off the retail price in your local pharmacy. Just print your coupon! It’s ready to use and never expire. Present your manufacturer copay card in most local pharmacies to get a discount on Cyclosporine every time. What are you waiting for? Claim your prescription drug card now!
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Cyclosporine volume of distribution
The steady state volume of distribution during intravenous dosing has been reported as 3 to 5 L/kg in solid organ transplant recipients. Cyclosporine is excreted in human milk.
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Cyclosporine
A cyclic undecapeptide from an extract of soil fungi. It is a powerful immunosupressant with a specific action on T-lymphocytes. It is used for the prophylaxis of graft rejection in organ and tissue transplantation. Cyclosporine is produced as a metabolite by the fungus species Cordyceps militaris. (From Martindale, The Extra Pharmacopoeia, 30th ed).
Cyclosporine mechanism of action
Cyclosporine binds to cyclophilin. The complex then inhibits calcineurin which is normally responsible for activating transcription of interleukin 2. Cyclosporine also inhibits lymphokine production and interleukin release. In ophthalmic applications, the precise mechanism of action is not known. Cyclosporine emulsion is thought to act as a partial immunomodulator in patients whose tear production is presumed to be suppressed due to ocular inflammation associated with keratoconjunctivitis sicca.
Dosage forms of Cyclosporine
|Neoral Oral Solution||100mg/mL||50mL Reconstitution Suspension||$240.00|
|Cyclosporine||0.05%||3mL Eye drops||$32.00|
|Cyclosporine||0.05%||9mL Eye drops||$74.00|
|Restasis||0.05%||30vials Vials (Eye Drops)||$51.65|
|Restasis||0.05%||90vials Vials (Eye Drops)||$171.00|
Apo-cyclosporine Oral Solution
Humans and other mammals
Indication of Cyclosporine
For treatment of transplant (kidney, liver, and heart) rejection, rheumatoid arthritis, severe psoriasis.
Toxicity of Cyclosporine
The oral LD sub 50 /sub is 2329 mg/kg in mice, 1480 mg/kg in rats, and 1000 mg/kg in rabbits. The I.V. LD sub 50 /sub is 148 mg/kg in mice, 104 mg/kg in rats, and 46 mg/kg in rabbits.
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What is a Restasis?
Restasis contain cyclosporine, which is an immunosuppressant. Cyclosporine can increase the production of tears, which was reduced by inflammation of the eyes (s). Restasis for the treatment of chronic dry eyes that may be caused by inflammation.
Do not touch the Restasis dropper on any surface, including the eyes or hands. Dropper is sterile. If it is dirty, it can cause an infection in the eyes.
Do not use this medicine while wearing contact lenses. Contact lenses can be re-inserted 15 minutes after the introduction of Restasis eye drops, unless otherwise indicated by your doctor.