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Price of Cytarabine
Cytarabine 1 gm vial
* price without discount in nearest pharmacy. Price may vary.
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Cytarabine volume of distribution
What is Cytarabine
A pyrimidine nucleoside analog that is used mainly in the treatment of leukemia, especially acute non-lymphoblastic leukemia. Cytarabine is an antimetabolite antineoplastic agent that inhibits the synthesis of DNA. Its actions are specific for the S phase of the cell cycle. It also has antiviral and immunosuppressant properties. (From Martindale, The Extra Pharmacopoeia, 30th ed, p472)
Cytarabine mechanism of action
Cytarabine acts through direct DNA damage and incorporation into DNA. Cytarabine is cytotoxic to a wide variety of proliferating mammalian cells in culture. It exhibits cell phase specificity, primarily killing cells undergoing DNA synthesis (S-phase) and under certain conditions blocking the progression of cells from the G1 phase to the S-phase. Although the mechanism of action is not completely understood, it appears that cytarabine acts through the inhibition of DNA polymerase. A limited, but significant, incorporation of cytarabine into both DNA and RNA has also been reported.
Dosage forms of Cytarabine
|Injection||intrathecal; intravenous; subcutaneous||100 mg/5mL|
|Injection||intrathecal; intravenous; subcutaneous||2 g/20mL|
|Injection||intravenous; subcutaneous||20 mg/mL|
Agila Jamp Canada Inc
Humans and other mammals
Indication of Cytarabine
For the treatment of acute non-lymphocytic leukemia, acute lymphocytic leukemia and blast phase of chronic myelocytic leukemia.
Toxicity of Cytarabine
Cytarabine syndrome may develop – it is characterized by fever, myalgia, bone pain, occasionally chest pain, maculopapular rash, conjunctivitis, and malaise.
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