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RX BIN: 015558
Group ID: DDN6600
Card Holder ID: DDN6600

Pharmacists and Patients support.

2018 Price of Tafinlar


60 capsules (75mg)

* price without discount in nearest pharmacy. Price may vary.

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Dabrafenib volume of distribution

Apparent volume of distribution (Vd/F) = 70.3 L. Distribution to the brain is restricted because dabrafenib is a substrate and undergoes efflux by P-glycoprotein and breast cancer resistance protein.

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What is Dabrafenib

Dabrafenib mesylate is a reversible ATP-competitive kinase inhibitor and targets the MAPK pathway. FDA approved on May 29, 2013.

Dabrafenib mechanism of action

Dabrafenib is an inhibitor of some mutated forms of BRAF kinases with in vitro IC50 values of 0.65, 0.5, and 1.84 nM for BRAF V600E, BRAF V600K, and BRAF V600D enzymes, respectively. Dabrafenib also inhibits wild-type BRAF and CRAF kinases with IC50 values of 3.2 and 5.0 nM, respectively, and other kinases such as SIK1, NEK11, and LIMK1 at higher concentrations. Some mutations in the BRAF gene, including those that result in BRAF V600E, can result in constitutively activated BRAF kinases that may stimulate tumor cell growth.

Dosage forms of Dabrafenib

Tafinlar50mg150 capsules$8,201
Tafinlar120mg56 Capsule$4,921
Tafinlar240mg56 Capsule$9,312
Prescription Generics


International Brands



Dabrafenib GSK2118436a


Novartis Pharmaceuticals Corporation

CAS number





Affected organisms

Humans and other mammals

Indication of Dabrafenib

Dabrafenib is indicated for the treatment of patients with unresectable or metastatic melanoma with BRAF V600E mutation as detected by an FDA-approved test.

Toxicity of Dabrafenib

Most common adverse reactions ( 20%) for dabrafenib are hyperkeratosis, headache, pyrexia, arthralgia, papilloma, alopecia, and palmar-plantar erythrodysesthesia syndrome.

RX24 Drugs Disclaimer: before buying a Dabrafenib on prescription, consult your healthcare provider. Content on this page is provided for informational purposes only. Any use of this information is at your own risk.

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