Save up -80% on Dabrafenib

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RX BIN: 015558
RX PCN: HT
Group ID: DDN6600
Card Holder ID: DDN6600

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2018 Price of Tafinlar

$4,788

60 capsules (75mg)

* price without discount in nearest pharmacy. Price may vary.

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We offer free Dabrafenib coupons and discounts that may help you save up to 80% off the retail price in your local pharmacy. Just print your coupon! It’s ready to use and never expire. Present your discount card in most local pharmacies to get a discount on Dabrafenib every time. What are you waiting for? Claim your prescription drug card now!

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Dabrafenib volume of distribution

Apparent volume of distribution (Vd/F) = 70.3 L. Distribution to the brain is restricted because dabrafenib is a substrate and undergoes efflux by P-glycoprotein and breast cancer resistance protein.

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What is Dabrafenib

Dabrafenib mesylate is a reversible ATP-competitive kinase inhibitor and targets the MAPK pathway. FDA approved on May 29, 2013.

Dabrafenib mechanism of action

Dabrafenib is an inhibitor of some mutated forms of BRAF kinases with in vitro IC50 values of 0.65, 0.5, and 1.84 nM for BRAF V600E, BRAF V600K, and BRAF V600D enzymes, respectively. Dabrafenib also inhibits wild-type BRAF and CRAF kinases with IC50 values of 3.2 and 5.0 nM, respectively, and other kinases such as SIK1, NEK11, and LIMK1 at higher concentrations. Some mutations in the BRAF gene, including those that result in BRAF V600E, can result in constitutively activated BRAF kinases that may stimulate tumor cell growth.

Dosage forms of Dabrafenib

DrugDosageQuantityPrice
Tafinlar50mg150 capsules$8,201
Tafinlar120mg56 Capsule$4,921
Tafinlar240mg56 Capsule$9,312
Prescription Generics

false

International Brands

Tafinlar

Synonyms

Dabrafenib GSK2118436a

Manufacturers

Novartis Pharmaceuticals Corporation

CAS number

UNII

QGP4HA4G1B

State

solid

Affected organisms

Humans and other mammals

Indication of Dabrafenib

Dabrafenib is indicated for the treatment of patients with unresectable or metastatic melanoma with BRAF V600E mutation as detected by an FDA-approved test.

Toxicity of Dabrafenib

Most common adverse reactions ( 20%) for dabrafenib are hyperkeratosis, headache, pyrexia, arthralgia, papilloma, alopecia, and palmar-plantar erythrodysesthesia syndrome.

RX24 Drugs Disclaimer: before buying a Dabrafenib on prescription, consult your healthcare provider. Content on this page is provided for informational purposes only. Any use of this information is at your own risk.

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