Save up -80% on Dacarbazine
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2018 Price of Dacarbazine
Dacarbazine 100 mg vial
* price without discount in nearest pharmacy. Price may vary.
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Dacarbazine volume of distribution
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Dacarbazine
An antineoplastic agent. It has significant activity against melanomas. (from Martindale, The Extra Pharmacopoeia, 31st ed, p564). Dacarbazine with Oblimersen is in clinical trials for the treatment of malignant melanoma.
Dacarbazine mechanism of action
The mechanism of action is not known, but appears to exert cytotoxic effects via its action as an alkylating agent. Other theories include DNA synthesis inhibition by its action as a purine analog, and interaction with SH groups. Dacarbazine is not cell cycle-phase specific.
Dosage forms of Dacarbazine
|Injection, powder, for solution||intravenous||10 mg/mL|
|Injection, powder, for solution||intravenous||200 mg/20mL|
|Powder for solution||intravenous||600 mg|
APP Pharmaceuticals, LLC
Humans and other mammals
Indication of Dacarbazine
For the treatment of metastatic malignant melanoma. In addition, dacarbazine is also indicated for Hodgkin’s disease as a secondary-line therapy when used in combination with other antineoplastic agents.
Toxicity of Dacarbazine
LDsub50/sub=350mg/kg (orally in mice)
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