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RX BIN: 015558
Group ID: DDN6600
Card Holder ID: DDN6600

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2018 Price of Dactinomycin

Cosmegen 0.5 mg vial



* price without discount in nearest pharmacy. Price may vary.

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Dactinomycin volume of distribution

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What is Dactinomycin

A compound composed of a two cyclic peptides attached to a phenoxazine that is derived from streptomyces parvullus. It binds to DNA and inhibits RNA synthesis (transcription), with chain elongation more sensitive than initiation, termination, or release. As a result of impaired mRNA production, protein synthesis also declines after dactinomycin therapy. (From AMA Drug Evaluations Annual, 1993, p2015)

Dactinomycin mechanism of action

Good evidence exists that this drug bind strongly, but reversibly, to DNA, interfering with synthesis of RNA (prevention of RNA polymerase elongation) and, consequently, with protein synthesis.

Dosage forms of Dactinomycin

Injection, powder, lyophilized, for solutionintravenous.5 mg/mL
Powder for solutionintravenous0.5 mg
Prescription Generics


International Brands



2-amino-N,N’-bis(hexadecahydro-2,5,9-trimethyl-6,13-bis(1-methylethyl)-1,4,7,11,14-pentaoxo-1H-pyrrolo(2,1-I)(1,4,7,10,13)oxatetra-azacyclohexadecin-10-yl)-4,6-dimethyl-3-oxo-3H-phenoxazine-1,9-dicarboxamide ActD


Recordati Rare Diseases Inc

CAS number






Affected organisms

Humans and other mammals

Indication of Dactinomycin

For the treatment of Wilms’ tumor, childhood rhabdomyosarcoma, Ewing’s sarcoma and metastatic, nonseminomatous testicular cancer as part of a combination chemotherapy and/or multi-modality treatment regimen

Toxicity of Dactinomycin


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