Save up -80% on Dactinomycin
Note: this is a drug discount program, not an insurance plan.
2018 Price of Dactinomycin
Cosmegen 0.5 mg vial
* price without discount in nearest pharmacy. Price may vary.
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Dactinomycin volume of distribution
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Dactinomycin
A compound composed of a two cyclic peptides attached to a phenoxazine that is derived from streptomyces parvullus. It binds to DNA and inhibits RNA synthesis (transcription), with chain elongation more sensitive than initiation, termination, or release. As a result of impaired mRNA production, protein synthesis also declines after dactinomycin therapy. (From AMA Drug Evaluations Annual, 1993, p2015)
Dactinomycin mechanism of action
Good evidence exists that this drug bind strongly, but reversibly, to DNA, interfering with synthesis of RNA (prevention of RNA polymerase elongation) and, consequently, with protein synthesis.
Dosage forms of Dactinomycin
|Injection, powder, lyophilized, for solution||intravenous||.5 mg/mL|
|Powder for solution||intravenous||0.5 mg|
Recordati Rare Diseases Inc
Humans and other mammals
Indication of Dactinomycin
For the treatment of Wilms’ tumor, childhood rhabdomyosarcoma, Ewing’s sarcoma and metastatic, nonseminomatous testicular cancer as part of a combination chemotherapy and/or multi-modality treatment regimen
Toxicity of Dactinomycin
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