Save up -80% on Danazol
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|RX BIN: 015558||RX PCN: HT||Group ID: DDN6600||Card Holder ID: DDN6600|
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2019 Price of Danocrine
|price without discount in nearest pharmacy. Price may vary.|
We offer free Danocrine coupons and discounts that may help you save up to 80% off the retail price in your local pharmacy. Just print your coupon! It’s ready to use and never expire. Present your manufacturer copay card in most local pharmacies to get a discount on Danazol every time. What are you waiting for? Claim your prescription drug card now!
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Danazol volume of distribution
Intake of danazol with food (>30 grams of fat) has been found to increase the bioavailability and peak levels of danazol by 3- to 4-fold with a single dose and by 2- to 2.5-fold with chronic administration. Following administration of danazol, peak concentrations occur after 2 to 8 hours, with a median of 4 hours. Steady-state levels of danazol are achieved after 6 days of twice-daily administration. Danazol is lipophilic and can partition into cell membranes, which indicates that it is likely to distribute deeply into tissue compartments. The volume of distribution of danazol is 3.4 L.
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Danazol
A synthetic steroid with antigonadotropic and anti-estrogenic activities that acts as an anterior pituitary suppressant by inhibiting the pituitary output of gonadotropins. It possesses some androgenic properties. Danazol has been used in the treatment of endometriosis and some benign breast disorders.
Danazol mechanism of action
As a gonadotropin inhibitor, danazol suppresses the pituitary-ovarian axis possibly by inhibiting the output of pituitary gonadotropins. Danazol also depresses the preovulatory surge in output of follicle-stimulating hormone (FSH) and luteinizing hormone (LH), thereby reducing ovarian estrogen production. Danazol may also directly inhibits ovarian steroidogenesis; bind to androgen, progesterone, and glucocorticoid receptors; bind to sex-hormone-binding globulin and corticosteroid-binding globulin; and increases the metabolic clearance rate of progesterone. Another mechanism of action by which danazol may use to facilitate regression of endometriosis is by decreasing IgG, IgM, and IgA concentrations, as well as phospholipid and IgG isotope autoantibodies. In the treatment of endometriosis, as a consequence of suppression of ovarian function, danazol causes both normal and ectopic endometrial tissues to become inactive and atrophic. This leads to anovulation and associated amenorrhea. In fibrocystic breast disease, the exact mechanism of action of danazol is unknown, but may be related to suppressed estrogenic stimulation as a result of decreased ovarian production of estrogen. A direct effect on steroid receptor sites in breast tissue is also possible. This leads to a disappearance of nodularity, relief of pain and tenderness, and possibly changes in the menstrual pattern. In terms of hereditary angioedema, danazol corrects the underlying biochemical deficiency by increasing serum concentrations of the deficient C1 esterase inhibitor, resulting in increased serum concentrations of the C4 component of the complement system. (Source: PharmGKB)
Dosage forms of Danazol
Sanofi Aventis Canada Inc
Humans and other mammals
Indication of Danazol
For the treatment of endometriosis and fibrocystic breast disease (in patients unresponsive to simple measures). Also used for the prophylactic treatment of all types of hereditary angioedema in males and females.
Toxicity of Danazol
Do not use danazol in patients with severe hepatic disease. Danazol should be used with caution, if at all, in patients with milder grades of hepatic disease. Danazol use can cause hepatotoxicity including cholestatic jaundice, peliosis hepatis, and benign hepatic adenoma. Peliosis hepatis and adenoma may not be apparent until patients present with life-threatening intra-abdominal hemorrhage.
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