Save up -80% on Dantrolene
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2018 Price of Dantrolene
Dantrolene sodium 25 mg capsule
* price without discount in nearest pharmacy. Price may vary.
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Dantrolene volume of distribution
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
Dantrolene mechanism of action
Dantrolene depresses excitation-contraction coupling in skeletal muscle by binding to the ryanodine receptor 1, and decreasing intracellular calcium concentration. Ryanodine receptors mediate the release of calcium from the sarcoplasmic reticulum, an essential step in muscle contraction.
Dosage forms of Dantrolene
Par Pharmaceutical Inc.
Humans and other mammals
Indication of Dantrolene
For use, along with appropriate supportive measures, for the management of the fulminant hypermetabolism of skeletal muscle characteristic of malignant hyperthermia crises in patients of all ages. Also used preoperatively, and sometimes postoperatively, to prevent or attenuate the development of clinical and laboratory signs of malignant hyperthermia in individuals judged to be malignant hyperthermia susceptible.
Toxicity of Dantrolene
Oral LD sub50 /sub in rats is 7400 mg/kg. Symptoms which may occur in case of overdose include, but are not limited to, muscular weakness and alterations in the state of consciousness (e.g., lethargy, coma), vomiting, diarrhea, and crystalluria.
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