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RX BIN: 015558RX PCN: HTGroup ID: DDN6600Card Holder ID: DDN6600
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2019 Price of Farxiga

$485.3230 tablets/10 mg
price without discount in nearest pharmacy. Price may vary.

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Dapagliflozin volume of distribution

Dose-proportional systemic exposure to dapagliflozin has been observed over a wide dose range (0.1-500 mg) with an oral bioavailability of 78 %. Dapagliflozin has extensive extravascular distribution (mean volume of distribution of 118 L).

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What is Dapagliflozin

Dapagliflozin is indicated for the management of diabetes mellitus type 2, and functions to improve glycemic control in adults when combined with diet and exercise. Dapagliflozin is a sodium-glucose cotransporter 2 inhibitor, which prevents glucose reabsorption in the kidney. Using dapagliflozin leads to heavy glycosuria (glucose excretion in the urine), which can lead to weight loss and tiredness. Dapagliflozin was approved by the FDA on Jan 08, 2014. Dapagliflozin is not recommended for patients with type 1 diabetes mellitus or for the treatment of diabetic ketoacidosis.

Dapagliflozin mechanism of action

A competitive inhibitor of the sodium-glucose transport subtype 2 protein, dapagliflozin blocks glucose reabsorption into the kidney, resulting in the elimination of blood glucose through the urine.

Dosage forms of Dapagliflozin

FormRouteStrength
Film-coated tabletOral use10 mg
Film-coated tabletOral use5 mg
Tablet, film coatedoral10 mg/1

Prescription Generics

false

International Brands

Farxiga

Synonyms

(2S,3R,4R,5S,6R)-2-(4-Chloro-3-(4-ethoxybenzyl)phenyl)-6- (hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol

Manufacturers

E.R. Squibb – Sons, L.L.C.

CAS number

461432-26-8

UNII

1ULL0QJ8UC

State

solid

Affected organisms

Humans and other mammals

Indication of Dapagliflozin

Dapagliflozin is indicated for adjunct management of glycemic control in patients with type 2 diabetes mellitus, in combination with diet and exercise.

Toxicity of Dapagliflozin

Compared to placebo-treated patients, patients with moderate renal impairment treated with dapagliflozin did not have improvement in glycemic control and had more renal-related adverse reactions and more bone fractures; therefore, dapagliflozin should not be initiated in this population. Based on its mechanism of action, dapagliflozin is not expected to be effective in patients with severe renal impairment (eGFR less than 30 mL/min/1.73 m2) or ESRD.

RX24 Drugs Disclaimer: consult your healthcare provider before buying a Dapagliflozin on prescription or using an RX manufacturer savings coupon. Content on this page is provided for informational purposes only. Any use of this information is at your own risk.

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What is Farxiga?

Farxiga is a cure for oral diabetes that helps control blood sugar levels. Dapagliflozin works by helping the kidneys get rid of glucose from your bloodstream.

Farxiga is used along with diet and exercise to treat type 2 diabetes. Farxiga is not intended for the treatment of type 1 diabetes.

You should not use Farxiga if you have severe kidney disease, if you are on dialysis, or if you have diabetic ketoacidosis. Farxiga is not intended for the treatment of type 1 diabetes.