Save up -80% on Daptomycin

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RX BIN: 015558
RX PCN: HT
Group ID: DDN6600
Card Holder ID: DDN6600

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2018 Price of Daptomycin

Cubicin 500 mg vial

$272.7

vial

* price without discount in nearest pharmacy. Price may vary.

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Daptomycin volume of distribution

* 0.1 L/Kg[healthy adult subjects]

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What is Daptomycin

Daptomycin is a lipopeptide antibiotic that kills susceptible gram positive bacteria by disrupting their membrane potential. It is a naturally-occurring compound found in the soil bacterium i Streptomyces roseosporus /i. Antibiotics are used in the treatment of infections caused by bacteria. They work by killing bacteria or preventing their growth. Daptomycin will not work for colds, flu, or other virus infections. It was approved in September 2003 for the treatment of complicated skin and soft tissue infections. It has a safety profile similar to other agents commonly administered to treat gram-positive infections.

Daptomycin mechanism of action

Daptomycin appears to bind or insert into the outer membrane of gram positive bacteria. The binding and integration of daptomycin into the cell membrane is calcium dependent. Calcium ions cause a conformational change in daptomycin, augmenting its amphipathicity (hydrophilic head group and hydrophobic tail group), leading to incorporation into the cell membrane. ; This binding causes rapid depolarisation, resulting in a loss of membrane potential leading to inhibition of protein, DNA and RNA synthesis, which results in bacterial cell death. The bactericidal activity of daptomycin is concentration-dependent. There is in vitro evidence of synergy with .-lactam antibiotics. ;

Dosage forms of Daptomycin

FormRouteStrength
Injection, powder, lyophilized, for solutionintravenous500 mg/10mL
Powder for solutionintravenous500 mg
Injection, powder, lyophilized, for solutionintravenous50 mg/mL
Prescription Generics

false

International Brands

Cubicin

Synonyms

Manufacturers

Merck Sharp Dohme Corp.

CAS number

103060-53-3

UNII

NWQ5N31VKK

State

solid

Affected organisms

Enteric bacteria and other eubacteria

Indication of Daptomycin

For the treatment of complicated skin and skin structure infections caused by susceptible strains of Gram-positive microorganisms.

Toxicity of Daptomycin

RX24 Drugs Disclaimer: before buying a Daptomycin on prescription, consult your healthcare provider. Content on this page is provided for informational purposes only. Any use of this information is at your own risk.

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