Save up -80% on Daptomycin
Note: this is a drug discount program, not an insurance plan.
2018 Price of Daptomycin
Cubicin 500 mg vial
* price without discount in nearest pharmacy. Price may vary.
We offer free Daptomycin coupons and discounts that may help you save up to 80% off the retail price in your local pharmacy. Just print your coupon! It’s ready to use and never expire. Present your discount card in most local pharmacies to get a discount on Daptomycin every time. What are you waiting for? Claim your prescription drug card now!
Daptomycin volume of distribution
* 0.1 L/Kg[healthy adult subjects]
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Daptomycin
Daptomycin is a lipopeptide antibiotic that kills susceptible gram positive bacteria by disrupting their membrane potential. It is a naturally-occurring compound found in the soil bacterium i Streptomyces roseosporus /i. Antibiotics are used in the treatment of infections caused by bacteria. They work by killing bacteria or preventing their growth. Daptomycin will not work for colds, flu, or other virus infections. It was approved in September 2003 for the treatment of complicated skin and soft tissue infections. It has a safety profile similar to other agents commonly administered to treat gram-positive infections.
Daptomycin mechanism of action
Daptomycin appears to bind or insert into the outer membrane of gram positive bacteria. The binding and integration of daptomycin into the cell membrane is calcium dependent. Calcium ions cause a conformational change in daptomycin, augmenting its amphipathicity (hydrophilic head group and hydrophobic tail group), leading to incorporation into the cell membrane. ; This binding causes rapid depolarisation, resulting in a loss of membrane potential leading to inhibition of protein, DNA and RNA synthesis, which results in bacterial cell death. The bactericidal activity of daptomycin is concentration-dependent. There is in vitro evidence of synergy with .-lactam antibiotics. ;
Dosage forms of Daptomycin
|Injection, powder, lyophilized, for solution||intravenous||500 mg/10mL|
|Powder for solution||intravenous||500 mg|
|Injection, powder, lyophilized, for solution||intravenous||50 mg/mL|
Merck Sharp Dohme Corp.
Enteric bacteria and other eubacteria
Indication of Daptomycin
For the treatment of complicated skin and skin structure infections caused by susceptible strains of Gram-positive microorganisms.
Toxicity of Daptomycin
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