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RX BIN: 015558
RX PCN: HT
Group ID: DDN6600
Card Holder ID: DDN6600

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2018 Price of Darbepoetin alfa

Aranesp 25 mcg/ml vial

$156.36

ml

* price without discount in nearest pharmacy. Price may vary.

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Darbepoetin alfa volume of distribution

FormRouteStrength
Injection, solutionintravenous; subcutaneous10 ug/.4mL
Injection, solutionintravenous; subcutaneous100 ug/.5mL
Injection, solutionintravenous; subcutaneous150 ug/.3mL

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What is Darbepoetin alfa

Human erythropoietin with 2 aa substitutions to enhance glycosylation (5 N-linked chains), 165 residues (MW=37 kD). Produced in Chinese hamster ovary (CHO) cells by recombinant DNA technology.

Darbepoetin alfa mechanism of action

Darbepoetin alfa stimulates erythropoiesis by the same mechanism as endogenous erythropoietin. Erythropoietin interacts with progenitor stem cells to increase red cell production. Binding of erythropoietin to the erythropoietin receptor leads to receptor dimerization, which facilitates activation of JAK-STAT signaling pathways within the cytosol. Activated STAT (signal transducers and activators of transcription) proteins are then translocated to the nucleus where they serve as transcription factors which regulate the activation of specific genes involved in cell division or differentiation.

Dosage forms of Darbepoetin alfa

DrugDosageQuantityPrice
Aranesp100mcg/ml1 carton (4 vials)$3,164
Aranesp200mcg/0.4ml2 syringes$3,166
Aranesp300mcg/ml4 vials$9,480
Prescription Generics

false

International Brands

Aranesp

Synonyms

Darbepoetin Darbepoetin alfa,recombinant

Manufacturers

Amgen Inc

CAS number

209810-58-2

UNII

15UQ94PT4P

State

liquid

Affected organisms

Humans and other mammals

Indication of Darbepoetin alfa

For the treatment of anemia (from renal transplants or certain HIV treatment)

Toxicity of Darbepoetin alfa

RX24 Drugs Disclaimer: before buying a Darbepoetin alfa on prescription, consult your healthcare provider. Content on this page is provided for informational purposes only. Any use of this information is at your own risk.

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