Save up -80% on Darbepoetin alfa
|Note: this is a drug discount program, not an insurance plan.|
|RX BIN: 015558||RX PCN: HT||Group ID: DDN6600||Card Holder ID: DDN6600|
|Pharmacists and Patients support.|
2019 Price of Aranesp
|$1,540.92||1 syringe 200mcg/0.4ml|
|price without discount in nearest pharmacy. Price may vary.|
We offer free Aranesp coupons and discounts that may help you save up to 80% off the retail price in your local pharmacy. Just print your coupon! It’s ready to use and never expire. Present your manufacturer copay card in most local pharmacies to get a discount on Darbepoetin alfa every time. What are you waiting for? Claim your prescription drug card now!
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Darbepoetin alfa volume of distribution
In another study designed to measure the pharmacokinetics of weekly subcutaneous injections of darbepoetin alfa at a dose of 2.25 μg/kg, the authors found a terminal half-life of 32.6 hours and a time to maximum concentration of 86.1 hours.
|Injection, solution||intravenous; subcutaneous||10 ug/.4mL|
|Injection, solution||intravenous; subcutaneous||100 ug/.5mL|
|Injection, solution||intravenous; subcutaneous||150 ug/.3mL|
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Darbepoetin alfa
Human erythropoietin with 2 aa substitutions to enhance glycosylation (5 N-linked chains), 165 residues (MW=37 kD). Produced in Chinese hamster ovary (CHO) cells by recombinant DNA technology.
Darbepoetin alfa mechanism of action
Darbepoetin alfa stimulates erythropoiesis by the same mechanism as endogenous erythropoietin. Erythropoietin interacts with progenitor stem cells to increase red cell production. Binding of erythropoietin to the erythropoietin receptor leads to receptor dimerization, which facilitates activation of JAK-STAT signaling pathways within the cytosol. Activated STAT (signal transducers and activators of transcription) proteins are then translocated to the nucleus where they serve as transcription factors which regulate the activation of specific genes involved in cell division or differentiation.
Dosage forms of Darbepoetin alfa
|Aranesp||100mcg/ml||1 carton (4 vials)||$3,164|
Darbepoetin Darbepoetin alfa,recombinant
Humans and other mammals
Indication of Darbepoetin alfa
For the treatment of anemia (from renal transplants or certain HIV treatment)
Toxicity of Darbepoetin alfa
Phase 3 trials comparing ESAs with placebo or standard of care for the treatment of anemia among patients with cancer. Mortality rates, VTE rates, and 95% confidence intervals (CIs) were extracted by 3 reviewers from 51 clinical trials with 13 611 patients that included survival information and 38 clinical trials with 8172 patients that included information on VTE. Patients with cancer who received ESAs had increased VTE risks (334 VTE events among 4610 patients treated with ESA vs 173 VTE events among 3562 control patients; 7.5% vs 4.9%; relative risk, 1.57; 95% CI, 1.31-1.87) and increased mortality risks (hazard ratio, 1.10; 95% CI, 1.01-1.20).
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