Save up -80% on Darbepoetin alfa
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Price of Darbepoetin alfa
Aranesp 25 mcg/ml vial
* price without discount in nearest pharmacy. Price may vary.
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Darbepoetin alfa volume of distribution
What is Darbepoetin alfa
Human erythropoietin with 2 aa substitutions to enhance glycosylation (5 N-linked chains), 165 residues (MW=37 kD). Produced in Chinese hamster ovary (CHO) cells by recombinant DNA technology.
Darbepoetin alfa mechanism of action
Darbepoetin alfa stimulates erythropoiesis by the same mechanism as endogenous erythropoietin. Erythropoietin interacts with
progenitor stem cells to increase red cell production. Binding of erythropoietin to the erythropoietin receptor leads to receptor dimerization, which facilitates activation of JAK-STAT signaling pathways within the cytosol. Activated STAT (signal transducers and activators of transcription) proteins are then translocated to the nucleus where they serve as transcription factors which regulate the activation of specific genes involved in cell division or differentiation.
Dosage forms of Darbepoetin alfa
|Injection, solution||intravenous; subcutaneous||10 ug/.4mL|
|Injection, solution||intravenous; subcutaneous||100 ug/.5mL|
|Injection, solution||intravenous; subcutaneous||150 ug/.3mL|
Humans and other mammals
Indication of Darbepoetin alfa
For the treatment of anemia (from renal transplants or certain HIV treatment)
Toxicity of Darbepoetin alfa
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