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RX BIN: 015558
RX PCN: HT
Group ID: DDN6600
Card Holder ID: DDN6600

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2018 Price of Darunavir

Prezista 75 mg tablet

$2.3

tablet

* price without discount in nearest pharmacy. Price may vary.

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Darunavir volume of distribution

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What is Darunavir

Darunavir is a protease inhibitor used to treat HIV. It acts on the HIV aspartyl protease which the virus needs to cleave the HIV polyprotein into its functional fragments.

Darunavir mechanism of action

Darunavir is a HIV protease inhibitor which prevents HIV replication by binding to the enzyme’s active site, thereby preventing the dimerization and the catalytic activity of the HIV-1 protease. Darunavir selectively inhibits the cleavage of HIV encoded Gag-Pol polyproteins in virus-infected cells, which prevents the formation of mature infectious virus particles. Structual analyses suggests that the close contact that darunavir has with the main chains of the protease active site amino acids (Asp-29 and Asp-30) is an important contributing factor to its potency and wide spectrum of activity against multi-protease inhibitor resistant HIV-1 variants. Darunavir can also adapt to the changing shape of a protease enzyme because of its molecular flexibility. Darunavir is known to bind to two distinct sites on the enzyme: the active site cavity and the surface of one of the flexible flaps in the protease dimer.

Dosage forms of Darunavir

DrugDosageQuantityPrice
Prezista400mg60 Tablet$448.90
Prezista600mg60 Tablet$535.00
Prescription Generics

false

International Brands

Pat-darunavir

Synonyms

(3R,3AS,6ar)-hexahydrofuro(2,3-b)furan-3-yl N-((1S,2R)-1-benzyl-2-hydroxy-3-(N(1)-isobutylsulfanilamido)propyl)carbamate (3R,3AS,6ar)-hexahydrofuro(2,3-b)furan-3-yl(1S,2R)-3-(((4-aminophenyl)sulfonyl)(isobutyl)amino)-1-benzyl-2-hydroxypropylcarbamate

Manufacturers

Patriot A Division Of Janssen Inc

CAS number

206361-99-1

UNII

YO603Y8113

State

solid

Affected organisms

Human Immunodeficiency Virus

Indication of Darunavir

Darunavir, co-administered with ritonavir, and with other antiretroviral agents, is indicated for the treatment of human immunodeficiency virus (HIV) infection in antiretroviral treatment-experienced adult patients, such as those with HIV-1 strains resistant to more than one protease inhibitor.

Toxicity of Darunavir

RX24 Drugs Disclaimer: before buying a Darunavir on prescription, consult your healthcare provider. Content on this page is provided for informational purposes only. Any use of this information is at your own risk.

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