Save up -80% on Dasatinib

Note: this is a drug discount program, not an insurance plan.

RX BIN: 015558
RX PCN: HT
Group ID: DDN6600
Card Holder ID: DDN6600

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2018 Price of Dasatinib

Sprycel 20 mg tablet

$69.56

tablet

* price without discount in nearest pharmacy. Price may vary.

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Dasatinib volume of distribution

* 2505 L

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What is Dasatinib

Dasatinib is an oral dual BCR/ABL and Src family tyrosine kinase inhibitor approved for use in patients with chronic myelogenous leukemia (CML). The main targets of Dasatinib, are BCRABL, SRC, Ephrins and GFR.

Dasatinib mechanism of action

Dasatinib, at nanomolar concentrations, inhibits the following kinases: BCR-ABL, SRC family (SRC, LCK, YES, FYN), c-KIT, EPHA2, and PDGFRbeta;. Based on modeling studies, dasatinib is predicted to bind to multiple conformations of the ABL kinase. In vitro, dasatinib was active in leukemic cell lines representing variants of imatinib mesylate sensitive and resistant disease. Dasatinib inhibited the growth of chronic myeloid leukemia (CML) and acute lymphoblastic leukemia (ALL) cell lines overexpressing BCR-ABL. Under the conditions of the assays, dasatinib was able to overcome imatinib resistance resulting from BCR-ABL kinase domain mutations, activation of alternate signaling pathways involving the SRC family kinases (LYN, HCK), and multi-drug resistance gene overexpression.

Dosage forms of Dasatinib

FormRouteStrength
Film-coated tabletOral use100 mg
Film-coated tabletOral use140 mg
Film-coated tabletOral use20 mg
Prescription Generics

false

International Brands

Sprycel

Synonyms

anh. dasatinib Anhydrous dasatinib

Manufacturers

E.R. Squibb Sons, L.L.C.

CAS number

302962-49-8

UNII

X78UG0A0RN

State

solid

Affected organisms

Humans and other mammals

Indication of Dasatinib

For the treatment of adults with chronic, accelerated, or myeloid or lymphoid blast phase chronic myeloid leukemia with resistance or intolerance to prior therapy. Also indicated for the treatment of adults with Philadelphia chromosome-positive acute lymphoblastic leukemia with resistance or intolerance to prior therapy.

Toxicity of Dasatinib

Acute overdose in animals was associated with cardiotoxicity.

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