Save up -80% on Dasatinib
|Note: this is a drug discount program, not an insurance plan.|
|RX BIN: 015558||RX PCN: HT||Group ID: DDN6600||Card Holder ID: DDN6600|
|Pharmacists and Patients support.|
2019 Price of Sprycel
|price without discount in nearest pharmacy. Price may vary.|
We offer free Dasatinib coupons and discounts that may help you save up to 80% off the retail price in your local pharmacy. Just print your coupon! It’s ready to use and never expire. Present your manufacturer copay card in most local pharmacies to get a discount on Dasatinib every time. What are you waiting for? Claim your prescription drug card now!
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Dasatinib volume of distribution
Dasatinib showed high volumes of distribution (>3 L/kg).
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Dasatinib
Dasatinib is an oral dual BCR/ABL and Src family tyrosine kinase inhibitor approved for use in patients with chronic myelogenous leukemia (CML). The main targets of Dasatinib, are BCRABL, SRC, Ephrins and GFR.
Dasatinib mechanism of action
Dasatinib, at nanomolar concentrations, inhibits the following kinases: BCR-ABL, SRC family (SRC, LCK, YES, FYN), c-KIT, EPHA2, and PDGFRbeta;. Based on modeling studies, dasatinib is predicted to bind to multiple conformations of the ABL kinase. In vitro, dasatinib was active in leukemic cell lines representing variants of imatinib mesylate sensitive and resistant disease. Dasatinib inhibited the growth of chronic myeloid leukemia (CML) and acute lymphoblastic leukemia (ALL) cell lines overexpressing BCR-ABL. Under the conditions of the assays, dasatinib was able to overcome imatinib resistance resulting from BCR-ABL kinase domain mutations, activation of alternate signaling pathways involving the SRC family kinases (LYN, HCK), and multi-drug resistance gene overexpression.
Dosage forms of Dasatinib
|Film-coated tablet||Oral use||100 mg|
|Film-coated tablet||Oral use||140 mg|
|Film-coated tablet||Oral use||20 mg|
anh. dasatinib Anhydrous dasatinib
E.R. Squibb Sons, L.L.C.
Humans and other mammals
Indication of Dasatinib
For the treatment of adults with chronic, accelerated, or myeloid or lymphoid blast phase chronic myeloid leukemia with resistance or intolerance to prior therapy. Also indicated for the treatment of adults with Philadelphia chromosome-positive acute lymphoblastic leukemia with resistance or intolerance to prior therapy.
Toxicity of Dasatinib
Acute overdose in animals was associated with cardiotoxicity.
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