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2018 Price of Deferiprone
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Deferiprone volume of distribution
In healthy patients, the volume of distribution is 1L/kg, and in thalassemia patients, the volume of distribution is 1.6L/kg.
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Deferiprone
Deferiprone is an oral iron chelator used as a second line agent in thalassemia syndromes when iron overload from blood transfusions occurs. Thalassemias are a type of hereditary anaemia due a defect in the production of hemoglobin. As a result, erythropoiesis, the production of new red blood cells, is impaired. FDA approved on October 14, 2011.
Deferiprone mechanism of action
Deferiprone is an iron chelator that binds to ferric ions (iron III) and forms a 3:1 (deferiprone:iron) stable complex and is then eliminated in the urine. Deferiprone is more selective for iron in which other metals such as zinc, copper, and aluminum have a lower affinity for deferiprone.
Dosage forms of Deferiprone
|Film-coated tablet||Oral use||1000 mg|
|Film-coated tablet||Oral use||500 mg|
|Oral solution||Oral use||100 mg/ml|
Humans and other mammals
Indication of Deferiprone
Deferiprone is indicated in thalassemia syndromes when first line chelation agents are not adequate to treat transfusional iron overload.
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