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RX BIN: 015558
Group ID: DDN6600
Card Holder ID: DDN6600

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2018 Price of Deferiprone


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Deferiprone volume of distribution

In healthy patients, the volume of distribution is 1L/kg, and in thalassemia patients, the volume of distribution is 1.6L/kg.

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What is Deferiprone

Deferiprone is an oral iron chelator used as a second line agent in thalassemia syndromes when iron overload from blood transfusions occurs. Thalassemias are a type of hereditary anaemia due a defect in the production of hemoglobin. As a result, erythropoiesis, the production of new red blood cells, is impaired. FDA approved on October 14, 2011.

Deferiprone mechanism of action

Deferiprone is an iron chelator that binds to ferric ions (iron III) and forms a 3:1 (deferiprone:iron) stable complex and is then eliminated in the urine. Deferiprone is more selective for iron in which other metals such as zinc, copper, and aluminum have a lower affinity for deferiprone.

Dosage forms of Deferiprone

Film-coated tabletOral use1000 mg
Film-coated tabletOral use500 mg
Oral solutionOral use100 mg/ml
Prescription Generics


International Brands



1,2-Dimethyl-3-hydroxypyrid-4-one 3-Hydroxy-1,2-dimethyl-4(1H)-pyridone


Apopharma Inc

CAS number






Affected organisms

Humans and other mammals

Indication of Deferiprone

Deferiprone is indicated in thalassemia syndromes when first line chelation agents are not adequate to treat transfusional iron overload.

Toxicity of Deferiprone

Agranulocytosis and neutropenia may occur, which can lead to fatal infections. Hepatoxicity is also possible. Most common side effects that lead to discontinuation of therapy were the gastrointestinal adverse effects (diarrhea, ulcer, nausea, gastrointestinal disturbances)

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