Save up -80% on Deferoxamine
|Note: this is a drug discount program, not an insurance plan.|
|RX BIN: 015558||RX PCN: HT||Group ID: DDN6600||Card Holder ID: DDN6600|
|Pharmacists and Patients support.|
2019 Price of Desferal
|Price with discount in nearest pharmacy. Price may vary.|
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Deferoxamine volume of distribution
DFO was found to be eliminated from the blood in a biexponential manner with a systemic clearance of 0.50 +/- 0.24 liters/hr/kg. The terminal half-life was 3.05 +/- 1.30 hr, and the volume of distribution was 1.88 +/- 1.0 liters/kg at the terminal phase and 1.35 +/- 0.65 liters/kg at steady state. The AUC of DFO was 354 +/- 131 mumol/liter.hr. The major metabolite of DFO, DFO-metabolite B, has an initial half-life of 1.33 +/- 0.61 hr and is usually present at lower concentrations relative to the parent compound with an AUC of 191 +/- 106 mumol/liter.hr.
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Deferoxamine
Natural product isolated from Streptomyces pilosus. It forms iron complexes and is used as a chelating agent, particularly in the mesylate form.
Deferoxamine mechanism of action
Deferoxamine works in treating iron toxicity by binding trivalent (ferric) iron (for which it has a strong affinity), forming ferrioxamine, a stable complex which is eliminated via the kidneys. 100 mg of deferoxamine is capable of binding approximately 8.5 mg of trivalent (ferric) iron. Deferoxamine works in treating aluminum toxicity by binding to tissue-bound aluminum to form aluminoxamine, a stable, water-soluble complex. The formation of aluminoxamine increases blood concentrations of aluminum, resulting in an increased concentration gradient between the blood and dialysate, boosting the removal of aluminum during dialysis. 100 mg of deferoxamine is capable of binding approximately 4.1 mg of aluminum.
Dosage forms of Deferoxamine
|Injection, powder, lyophilized, for solution||intramuscular; intravenous; subcutaneous||95 mg/mL|
|Injection, powder, lyophilized, for solution||intramuscular; intravenous; subcutaneous||2 g/1|
|Injection, powder, lyophilized, for solution||intramuscular; intravenous; subcutaneous||500 mg/1|
APP Pharmaceuticals, LLC
Humans and other mammals
Indication of Deferoxamine
Used to treat acute iron or aluminum toxicity (an excess of aluminum in the body) in certain patients. Also used in certain patients with anemia who must receive many blood transfusions.
Toxicity of Deferoxamine
Intravenous LD sub50 /sub in mouse, rat, and rabbit is 340 mg/kg, 520 mg/kg, and 600 mg/kg, respectively. Subcutaneous LD sub50 /sub in mouse and rat is 1600 mg/kg and 1000 mg/kg, respectively. Oral LD sub50 /sub in mouse and rat is 3000 mg/kg and 1000 mg/kg, respectively. Nephrotoxicity, ototoxicity and retinal toxicity have been reported following long-term administration for chronic iron overload.
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