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Price of Deferoxamine
Desferrioxamine Mesilate 500 mg/vial
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Deferoxamine volume of distribution
What is Deferoxamine
Natural product isolated from Streptomyces pilosus. It forms iron complexes and is used as a chelating agent, particularly in the mesylate form. (PubChem)
Deferoxamine mechanism of action
Deferoxamine works in treating iron toxicity by binding trivalent (ferric) iron (for which it has a strong affinity), forming ferrioxamine, a stable complex which is eliminated via the kidneys. 100 mg of deferoxamine is capable of binding approximately 8.5 mg of trivalent (ferric) iron. Deferoxamine works in treating aluminum toxicity by binding to tissue-bound aluminum to form aluminoxamine, a stable, water-soluble complex. The formation of aluminoxamine increases blood concentrations of aluminum, resulting in an increased concentration gradient between the blood and dialysate, boosting the removal of aluminum during dialysis. 100 mg of deferoxamine is capable of binding approximately 4.1 mg of aluminum.
Dosage forms of Deferoxamine
|Injection, powder, lyophilized, for solution||intramuscular; intravenous; subcutaneous||95 mg/mL|
|Injection, powder, lyophilized, for solution||intramuscular; intravenous; subcutaneous||2 g/1|
|Injection, powder, lyophilized, for solution||intramuscular; intravenous; subcutaneous||500 mg/1|
APP Pharmaceuticals, LLC
Humans and other mammals
Indication of Deferoxamine
Used to treat acute iron or aluminum toxicity (an excess of aluminum in the body) in certain patients. Also used in certain patients with anemia who must receive many blood transfusions.
Toxicity of Deferoxamine
Intravenous LD sub50 /sub in mouse, rat, and rabbit is 340 mg/kg, 520 mg/kg, and 600 mg/kg, respectively. Subcutaneous LD sub50 /sub in mouse and rat is 1600 mg/kg and 1000 mg/kg, respectively. Oral LD sub50 /sub in mouse and rat is 3000 mg/kg and 1000 mg/kg, respectively. Nephrotoxicity, ototoxicity and retinal toxicity have been reported following long-term administration for chronic iron overload.
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