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RX BIN: 015558
RX PCN: HT
Group ID: DDN6600
Card Holder ID: DDN6600

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2018 Price of Deferoxamine

Desferrioxamine Mesilate 500 mg/vial

$8.44

vial

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Deferoxamine volume of distribution

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What is Deferoxamine

Natural product isolated from Streptomyces pilosus. It forms iron complexes and is used as a chelating agent, particularly in the mesylate form.

Deferoxamine mechanism of action

Deferoxamine works in treating iron toxicity by binding trivalent (ferric) iron (for which it has a strong affinity), forming ferrioxamine, a stable complex which is eliminated via the kidneys. 100 mg of deferoxamine is capable of binding approximately 8.5 mg of trivalent (ferric) iron. Deferoxamine works in treating aluminum toxicity by binding to tissue-bound aluminum to form aluminoxamine, a stable, water-soluble complex. The formation of aluminoxamine increases blood concentrations of aluminum, resulting in an increased concentration gradient between the blood and dialysate, boosting the removal of aluminum during dialysis. 100 mg of deferoxamine is capable of binding approximately 4.1 mg of aluminum.

Dosage forms of Deferoxamine

FormRouteStrength
Injection, powder, lyophilized, for solutionintramuscular; intravenous; subcutaneous95 mg/mL
Injection, powder, lyophilized, for solutionintramuscular; intravenous; subcutaneous2 g/1
Injection, powder, lyophilized, for solutionintramuscular; intravenous; subcutaneous500 mg/1
Prescription Generics

true

International Brands

Deferoxamine

Synonyms

Deferoxamin Deferoxamina

Manufacturers

APP Pharmaceuticals, LLC

CAS number

70-51-9

UNII

J06Y7MXW4D

State

solid

Affected organisms

Humans and other mammals

Indication of Deferoxamine

Used to treat acute iron or aluminum toxicity (an excess of aluminum in the body) in certain patients. Also used in certain patients with anemia who must receive many blood transfusions.

Toxicity of Deferoxamine

Intravenous LD sub50 /sub in mouse, rat, and rabbit is 340 mg/kg, 520 mg/kg, and 600 mg/kg, respectively. Subcutaneous LD sub50 /sub in mouse and rat is 1600 mg/kg and 1000 mg/kg, respectively. Oral LD sub50 /sub in mouse and rat is 3000 mg/kg and 1000 mg/kg, respectively. Nephrotoxicity, ototoxicity and retinal toxicity have been reported following long-term administration for chronic iron overload.

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