Save up -80% on Denileukin diftitox
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Price of Denileukin diftitox
Ontak 150 mcg/ml vial
* price without discount in nearest pharmacy. Price may vary.
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Denileukin diftitox volume of distribution
* 0.06 to 0.09 L/kg
What is Denileukin diftitox
A recombinant DNA-derived cytotoxic protein composed of the amino acid sequences for diphtheria toxin fragments A and B (Met 1-Thr 387)-His followed by the sequences for interleukin-2 (IL-2; Ala 1-Thr 133). It is produced in an E. coli expression system.
Denileukin diftitox mechanism of action
Denileukin diftitox binds to the high-affinity IL-2 receptor complex. The IL-2 receptor (Tac) subunit is expressed on activated but not resting lymphocytes. The diphtheria toxin associated with Ontak then selectively kills the IL-2 bearing cells.
Dosage forms of Denileukin diftitox
|Injection, solution||intravenous||150 ug/mL|
Diphtheria toxin precursor
Humans and other mammals
Indication of Denileukin diftitox
For treatment of cutaneous T-cell lymphoma
Toxicity of Denileukin diftitox
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