Save up -80% on Deoxycholic Acid
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2018 Price of Deoxycholic Acid
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Deoxycholic Acid volume of distribution
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Deoxycholic Acid
Deoxycholic acid is a a bile acid which emulsifies and solubilizes dietary fats in the intestine, and when injected subcutaneously, it disrupts cell membranes in adipocytes and destroys fat cells in that tissue. In April 2015, deoxycholic acid was approved by the FDA for the treatment submental fat to improve aesthetic appearance and reduce facial fullness or convexity. It is marketed under the brand name Kybella by Kythera Biopharma and is the first pharmacological agent available for submental fat reduction, allowing for a safer and less invasive alternative than surgical procedures.
Deoxycholic Acid mechanism of action
As a bile acid, deoxycholic acid emulsifies fat in the gut. Synthetically derived deoxycholic acid, when injected, stimulates a targeted breakdown of adipose cells by disrupting the cell membrane and causing adipocytolysis. This results in an inflammatory reaction and clearing of the adipose tissue remnants by macrophages. Deoxycholic acid’s actions are reduced by albumin and tissue-associated proteins, therefore its effect is limited to protein-poor subcutaneous fat tissue. Protein-rich tissues like muscle and skin are unaffected by deoxycholic acid, contributing to its safety profile.
Dosage forms of Deoxycholic Acid
|Injection, solution||subcutaneous||20 mg/2mL|
(3 ,5 ,12 )-3,12-dihydroxycholan-24-oic acid 3alpha,12alpha-Dihydroxy-5beta-cholanic acid
Kythera Biopharmaceuticals, Inc.
Humans and other mammals
Indication of Deoxycholic Acid
For improvement in appearance of moderate to severe fullness associated with submental fat in adults.
Toxicity of Deoxycholic Acid
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