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RX BIN: 015558
RX PCN: HT
Group ID: DDN6600
Card Holder ID: DDN6600

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2018 Price of Desmopressin

Apo-Desmopressin 10 mcg/dose Metered Dose Spray

$1.48

dose

* price without discount in nearest pharmacy. Price may vary.

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Desmopressin volume of distribution

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What is Desmopressin

Desmopressin is a chemical that is similar to Antidiuretic Hormone (ADH) which is found naturally in the body. It increases urine concentration and decreases urine production. Desmopressin is used to prevent and control excessive thirst, urination, and dehydration caused by injury, surgery, and certain medical conditions, allowing you to sleep through the night without awakening to urinate. It is also used to treat specific types of diabetes insipidus and conditions after head injury or pituitary surgery.

Desmopressin mechanism of action

Desmopressin emulates the actions of endogenous human ADH (refer to Pharmacology section above). Desmpressin is a structural analogue of ADH modified by deamination of 1-cysteine and substitution of 8-L-arginine by 8-D-arginine. Compared to natural ADH, desmopressin elicits a great antidiuretic response on weight basis.

Dosage forms of Desmopressin

FormRouteStrength
Solutionintravenous4 ug/mL
Spraynasal.1 ug/mL
Tabletoral.1 mg/1
Prescription Generics

true

International Brands

Apo-desmopressin

Synonyms

1-(3-mercaptopropionic acid)-8-D-arginine-vasopressin 1-deamino-8-D-arginine vasopressin

Manufacturers

Apotex Inc

CAS number

16679-58-6

UNII

ENR1LLB0FP

State

solid

Affected organisms

Humans and other mammals

Indication of Desmopressin

Oral formulations may be used to manage primary nocturnal enuresis in adults and vasopressin sensitive diabetes insipidus, and for control of temporary polyuria and polydipsia following head trauma or surgery in the pituitary region. Intranasal and parenteral formulations may be used to manage spontaneous or trauma-induced bleeds (e.g. hemarthrosis, intramuscular hematoma, mucosal bleeding) in patients with hemophilia A or von Willebrand’s disease Type I. May also be used parenterally to prevent or treat bleeding in patients with uremia.

Toxicity of Desmopressin

Overdose may lead to increased duration of action and lead to symptoms such as fluid retention, headaches, abdominal cramps, nausea, and facial flushing. Adverse effects include headache, nausea, abdominal pain, facial flushing, dizziness, dry mouth, and hyponatremia. Nasal congestion and rhinitis have been reported with nasal spray formulations.

RX24 Drugs Disclaimer: before buying a Desmopressin on prescription, consult your healthcare provider. Content on this page is provided for informational purposes only. Any use of this information is at your own risk.

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