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Price of Dexamethasone
Dexamethasone 6 mg tablet
* price without discount in nearest pharmacy. Price may vary.
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Dexamethasone volume of distribution
What is Dexamethasone
An anti-inflammatory 9-fluoro-glucocorticoid. (PubChem)
Dexamethasone mechanism of action
Dexamethasone is a glucocorticoid agonist. Unbound dexamethasone crosses cell membranes and binds with high affinity to specific cytoplasmic glucocorticoid receptors. This complex binds to DNA elements (glucocorticoid response elements) which results in a modification of transcription and, hence, protein synthesis in order to achieve inhibition of leukocyte infiltration at the site of inflammation, interference in the function of mediators of inflammatory response, suppression of humoral immune responses, and reduction in edema or scar tissue. The antiinflammatory actions of dexamethasone are thought to involve phospholipase A sub2 /sub inhibitory proteins, lipocortins, which control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes.
Dosage forms of Dexamethasone
|Implant||nil; refer (see dosage form)||.7 mg|
999 Itch Relief
China Resources Sanjiu Medical Pharmaceutical Co Ltd
Humans and other mammals
Indication of Dexamethasone
BInjection: /B for the treatment of endocrine disorders, rheumatic D=disorders, collagen diseases, dermatologic diseases, allergic statesc, ophthalmic diseases, gastrointestinal diseases, respiratory diseases, hematologic disorders, neoplastic diseases, edematous states, cerebral edema.
br BOphthalmic ointment and solution: /B for the treatment of steroid responsive inflammatory conditions of the palpebral and bulbar conjunctiva, cornea, and anterior segment of the globe.
br BOphthalmic solution only: /B for the treatment of steroid responsive inflammatory conditions of the external auditory meatus
br BTopic cream: /B for relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses
br BOral aerosol: /B for the treatment of bronchial asthma and related corticosteroid responsive bronchospastic states intractable to adequate trial of conventional therapy
br BIntranasal aerosol: /B for the treatment of allergic ot inflammatory nasal conditions, and nasal polyps
Toxicity of Dexamethasone
Oral, rat LD sub50 /sub: 3 gm/kg. Signs of overdose include retinal toxicity, glaucoma, subcapsular cataract, gastrointestinal bleeding, pancreatitis, aseptic bone necrosis, osteoporosis, myopathies, obesity, edemas, hypertension, proteinuria, diabetes, sleep disturbances, psychiatric syndromes, delayed wound healing, atrophy and fragility of the skin, ecchymosis, and pseudotumor cerebri.
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