Save up -80% on Dexrazoxane

Note: this is a drug discount program, not an insurance plan.

RX BIN: 015558
RX PCN: HT
Group ID: DDN6600
Card Holder ID: DDN6600

Pharmacists and Patients support.

2018 Price of Dexrazoxane

Dexrazoxane 250 mg vial

$246.28

vial

* price without discount in nearest pharmacy. Price may vary.

Claim your free Dexrazoxane discount card

We offer free Dexrazoxane coupons and discounts that may help you save up to 80% off the retail price in your local pharmacy. Just print your coupon! It’s ready to use and never expire. Present your discount card in most local pharmacies to get a discount on Dexrazoxane every time. What are you waiting for? Claim your prescription drug card now!

Get your Prescription
It’s safe and free
Buy drugs in pharmacy
Save money each time

Dexrazoxane volume of distribution

* 9 to 22.6 L/m^2

About RX24Drugs

Discount Cards 16,000+

Clients Benefit 29%

Total savings $4,735,080

What is Dexrazoxane

An antimitotic agent with immunosuppressive properties. Dexrazoxane, the (+)-enantiomorph of razoxane, provides cardioprotection against anthracycline toxicity. It appears to inhibit formation of a toxic iron-anthracycline complex. The Food and Drug Administration has designated dexrazoxane as an orphan drug for use in the prevention or reduction in the incidence and severity of anthracycline-induced cardiomyopathy.

Dexrazoxane mechanism of action

The mechanism by which dexrazoxane exerts its cardioprotective activity is not fully understood. Dexrazoxane is a cyclic derivative of EDTA that readily penetrates cell membranes. Results of laboratory studies suggest that dexrazoxane (a prodrug) is converted intracellularly to a ring-opened bidentate chelating agent that chelates to free iron and interferes with iron-mediated free radical generation thought to be responsible, in part, for anthracycline-induced cardiomyopathy. It should be noted that dexrazoxane may also be protective through its inhibitory effect on topoisomerase II.

Dosage forms of Dexrazoxane

FormRouteStrength
Kit
Powder for concentrate and diluent for solution for infusionIntravenous use20 mg/ml
Injection, powder, lyophilized, for solutionintravenous250 mg/25mL
Prescription Generics

true

International Brands

Dexrazoxane Hydrochloride

Synonyms

(+)-(S)-4,4′-Propylenedi-2,6-piperazinedione (+)-1,2-Bis(3,5-dioxo-1-piperazinyl)propane

Manufacturers

Mylan Institutional LLC

CAS number

24584-09-6

UNII

048L81261F

State

solid

Affected organisms

Humans and other mammals

Indication of Dexrazoxane

For reducing the incidence and severity of cardiomyopathy associated with doxorubicin administration in women with metastatic breast cancer who have received a cumulative doxorubicin hydrochloride dose of 300 mg/m^2 and would benefit from continued doxorubicin therapy. Also approved for the treatment of extravasation from intravenous anthracyclines.

Toxicity of Dexrazoxane

Intraperitoneal, mouse LD sub 10 /sub = 500 mg/kg. Intravenous, dog LD sub 10 /sub = 2 gm/kg.

RX24 Drugs Disclaimer: before buying a Dexrazoxane on prescription, consult your healthcare provider. Content on this page is provided for informational purposes only. Any use of this information is at your own risk.

Get lower price on Dexrazoxane now!