Save up -80% on Dexrazoxane
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2018 Price of Dexrazoxane
Dexrazoxane 250 mg vial
* price without discount in nearest pharmacy. Price may vary.
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Dexrazoxane volume of distribution
* 9 to 22.6 L/m^2
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Dexrazoxane
An antimitotic agent with immunosuppressive properties. Dexrazoxane, the (+)-enantiomorph of razoxane, provides cardioprotection against anthracycline toxicity. It appears to inhibit formation of a toxic iron-anthracycline complex. The Food and Drug Administration has designated dexrazoxane as an orphan drug for use in the prevention or reduction in the incidence and severity of anthracycline-induced cardiomyopathy.
Dexrazoxane mechanism of action
The mechanism by which dexrazoxane exerts its cardioprotective activity is not fully understood. Dexrazoxane is a cyclic derivative of EDTA that readily penetrates cell membranes. Results of laboratory studies suggest that dexrazoxane (a prodrug) is converted intracellularly to a ring-opened bidentate chelating agent that chelates to free iron and interferes with iron-mediated free radical generation thought to be responsible, in part, for anthracycline-induced cardiomyopathy. It should be noted that dexrazoxane may also be protective through its inhibitory effect on topoisomerase II.
Dosage forms of Dexrazoxane
|Powder for concentrate and diluent for solution for infusion||Intravenous use||20 mg/ml|
|Injection, powder, lyophilized, for solution||intravenous||250 mg/25mL|
Mylan Institutional LLC
Humans and other mammals
Indication of Dexrazoxane
For reducing the incidence and severity of cardiomyopathy associated with doxorubicin administration in women with metastatic breast cancer who have received a cumulative doxorubicin hydrochloride dose of 300 mg/m^2 and would benefit from continued doxorubicin therapy. Also approved for the treatment of extravasation from intravenous anthracyclines.
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