Save up -80% on Dexrazoxane

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RX BIN: 015558RX PCN: HTGroup ID: DDN6600Card Holder ID: DDN6600
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2019 Price of Zinecard

$246.28vial
price without discount in nearest pharmacy. Price may vary.

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Dexrazoxane volume of distribution

* 9 to 22.6 L/m^2

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2018 Statistics

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Discount Cards 16,000+

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Clients Benefit 29%

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Total savings $4,735,080

What is Dexrazoxane

An antimitotic agent with immunosuppressive properties. Dexrazoxane, the (+)-enantiomorph of razoxane, provides cardioprotection against anthracycline toxicity. It appears to inhibit formation of a toxic iron-anthracycline complex. The Food and Drug Administration has designated dexrazoxane as an orphan drug for use in the prevention or reduction in the incidence and severity of anthracycline-induced cardiomyopathy.

Dexrazoxane mechanism of action

The mechanism by which dexrazoxane exerts its cardioprotective activity is not fully understood. Dexrazoxane is a cyclic derivative of EDTA that readily penetrates cell membranes. Results of laboratory studies suggest that dexrazoxane (a prodrug) is converted intracellularly to a ring-opened bidentate chelating agent that chelates to free iron and interferes with iron-mediated free radical generation thought to be responsible, in part, for anthracycline-induced cardiomyopathy. It should be noted that dexrazoxane may also be protective through its inhibitory effect on topoisomerase II.

Dosage forms of Dexrazoxane

FormRouteStrength
Kit
Powder for concentrate and diluent for solution for infusionIntravenous use20 mg/ml
Injection, powder, lyophilized, for solutionintravenous250 mg/25mL

Prescription Generics

true

International Brands

Dexrazoxane Hydrochloride

Synonyms

(+)-(S)-4,4′-Propylenedi-2,6-piperazinedione (+)-1,2-Bis(3,5-dioxo-1-piperazinyl)propane

Manufacturers

Mylan Institutional LLC

CAS number

24584-09-6

UNII

048L81261F

State

solid

Affected organisms

Humans and other mammals

Indication of Dexrazoxane

For reducing the incidence and severity of cardiomyopathy associated with doxorubicin administration in women with metastatic breast cancer who have received a cumulative doxorubicin hydrochloride dose of 300 mg/m^2 and would benefit from continued doxorubicin therapy. Also approved for the treatment of extravasation from intravenous anthracyclines.

Toxicity of Dexrazoxane

Intraperitoneal, mouse LD sub 10 /sub = 500 mg/kg. Intravenous, dog LD sub 10 /sub = 2 gm/kg.

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