Save up -80% on Dextroamphetamine
|Note: this is a drug discount program, not an insurance plan.|
|RX BIN: 015558||RX PCN: HT||Group ID: DDN6600||Card Holder ID: DDN6600|
|Pharmacists and Patients support.|
2019 Price of Zenzedi
|$42.08||60 tablets/10 mg|
|price without discount in nearest pharmacy. Price may vary.|
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Dextroamphetamine volume of distribution
A one-compartment plasma model linked to a single compartment for hair successfully described the pharmacokinetics of dextroamphetamine in healthy adults. The volume of distribution and clearance of dextroamphetamine increased with weight, and the volume of distribution of the hair compartment increased with greater melanin concentrations.
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Dextroamphetamine
Dextroamphetamine is the dextrorotary stereoisomer of the amphetamine molecule, which can take two different forms. It is a slightly polar, weak base and is lipophilic.
Dextroamphetamine mechanism of action
The exact mechanism of action is not known. Dextroamphetamine stimulates the release of norepinephrine from central adrenergic receptors. At higher dosages, it causes release of dopamine from the mesocorticolimbic system and the nigrostriatal dopamine systems by reversal of the monoamine transporters. Dextroamphetamine may also act as a direct agonist on central 5-HT receptors and may inhibit monoamine oxidase (MAO). In the periphery, amphetamines are believed to cause the release of noradrenaline by acting on the adrenergic nerve terminals and alpha- and beta-receptors. Modulation of serotonergic pathways may contribute to the calming affect.
Dosage forms of Dextroamphetamine
|Capsule (extended release)||oral|
|Capsule (sustained-release)||oral||10 mg|
|Capsule (sustained-release)||oral||15 mg|
Act Amphetamine XR
Actavis Pharma Company
Humans and other mammals
Indication of Dextroamphetamine
Used to treat attention deficit hyperactivity disorder (ADHD).
Toxicity of Dextroamphetamine
In rats, the oral LD50 of dextroamphetamine sulfate is 96.8 mg/kg. Manifestations of acute overdosage with amphetamines include restlessness, tremor, hyperreflexia, rhabdomyolysis, rapid respiration, hyperpyrexia, confusion, assaultiveness, hallucinations, panic states. Fatigue and depression usually follow the central stimulation. Cardiovascular effects include arrhythmias, hypertension or hypotension, and circulatory collapse. Gastrointestinal symptoms include nausea, vomiting, diarrhea, and abdominal cramps. Fatal poisoning is usually preceded by convulsions and coma.
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What is Zenzedi?
Zenzedi is an immediate-release stimulant medication — a tablet taken orally that is primarily used to treat narcolepsy and ADHD in children and adolescents ages 3-16. According to the FDA, Zenzedi is a federally controlled substance (CII) because it can be abused or lead to dependence. It is an amphetamine.
Zenzedi may improve focus and decrease impulsivity and hyperactive behavior, two hallmark symptoms for some patients with ADHD.
The American Academy of Pediatrics recommends treatment with behavioral therapy before medication for children under the age of 6. For children ages 6 to 11, the AAP says most effective treatments for ADHD are parental behavior therapy and/or ADHD stimulants. Likewise, the National Institute of Mental Health finds the most successful treatment plans use a combination of ADHD medication, like Zenzedi, and behavior therapies.