Save up -80% on Diazoxide
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2018 Price of Diazoxide
Proglycem 100 mg Capsule
* price without discount in nearest pharmacy. Price may vary.
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Diazoxide volume of distribution
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Diazoxide
A benzothiadiazine derivative that is a peripheral vasodilator used for hypertensive emergencies. It lacks diuretic effect, apparently because it lacks a sulfonamide group.
Diazoxide mechanism of action
As a diuretic, diazoxide inhibits active chloride reabsorption at the early distal tubule via the Na-Cl cotransporter, resulting in an increase in the excretion of sodium, chloride, and water. Thiazides like diazoxide also inhibit sodium ion transport across the renal tubular epithelium through binding to the thiazide sensitive sodium-chloride transporter. This results in an increase in potassium excretion via the sodium-potassium exchange mechanism. The antihypertensive mechanism of diazoxide is less well understood although it may be mediated through its action on carbonic anhydrases in the smooth muscle or through its action on the large-conductance calcium-activated potassium (KCa) channel, also found in the smooth muscle. As a antihypoglycemic, diazoxide inhibits insulin release from the pancreas, probably by opening potassium channels in the beta cell membrane.
Dosage forms of Diazoxide
Hyperstat Inj 15mg/ml
Schering Plough Canada Inc
Humans and other mammals
Indication of Diazoxide
Used parentally to treat hypertensive emergencies. Also used to treat hypoglycemia secondary to insulinoma.
Toxicity of Diazoxide
Oral LD sub50 /sub in rat and mouse: 980 mg/kg and 444 mg/kg, respectively.
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