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RX BIN: 015558RX PCN: HTGroup ID: DDN6600Card Holder ID: DDN6600
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Diazoxide volume of distribution

Diazoxide disposition in the body was described by a 1-compartment model. Oral clearance (CL/F) and the volume of distribution were proportional to body weight (WT), as expressed by CL/F in males (liters/h) = 0.0358 + 0.00374 × WT (kg). CL/F in females was 39% greater than that in males.

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2018 Statistics

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Discount Cards 16,000+

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Clients Benefit 29%

savings

Total savings $4,735,080

What is Diazoxide

A benzothiadiazine derivative that is a peripheral vasodilator used for hypertensive emergencies. It lacks diuretic effect, apparently because it lacks a sulfonamide group.

Diazoxide mechanism of action

As a diuretic, diazoxide inhibits active chloride reabsorption at the early distal tubule via the Na-Cl cotransporter, resulting in an increase in the excretion of sodium, chloride, and water. Thiazides like diazoxide also inhibit sodium ion transport across the renal tubular epithelium through binding to the thiazide sensitive sodium-chloride transporter. This results in an increase in potassium excretion via the sodium-potassium exchange mechanism. The antihypertensive mechanism of diazoxide is less well understood although it may be mediated through its action on carbonic anhydrases in the smooth muscle or through its action on the large-conductance calcium-activated potassium (KCa) channel, also found in the smooth muscle. As a antihypoglycemic, diazoxide inhibits insulin release from the pancreas, probably by opening potassium channels in the beta cell membrane.

Dosage forms of Diazoxide

FormRouteStrength
Liquidintravenous15 mg
Capsuleoral100 mg
Suspensionoral50 mg/mL

Prescription Generics

false

International Brands

Hyperstat Inj 15mg/ml

Synonyms

Diazossido Diazoxide

Manufacturers

Schering Plough Canada Inc

CAS number

364-98-7

UNII

O5CB12L4FN

State

solid

Affected organisms

Humans and other mammals

Indication of Diazoxide

Used parentally to treat hypertensive emergencies. Also used to treat hypoglycemia secondary to insulinoma.

Toxicity of Diazoxide

Oral LD sub50 /sub in rat and mouse: 980 mg/kg and 444 mg/kg, respectively.

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