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RX BIN: 015558RX PCN: HTGroup ID: DDN6600Card Holder ID: DDN6600
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2019 Price of Videx

$142.0730 capsules/125mg
Price with discount in nearest pharmacy. Price may vary.

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Didanosine volume of distribution

The apparent volume of distribution of didanosine following IV administration averages 1.08 l/kg in adult patient sand 28 l/sq m in pediatric patients. Didanosine is distributed into CSF following iv administration; CSF concentrations average 21% of concurrent plasma concentrations in samples obtained 1 hr after a dose of the drug. In one study in children and adolescents with symptomatic HIV infection who received a single oral dose or iv dose of didanosine, CSF concentrations were 46% (12-85%) of concurrent plasma concentrations.

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What is Didanosine

A dideoxynucleoside compound in which the 3 #39;-hydroxy group on the sugar moiety has been replaced by a hydrogen. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. Didanosine is a potent inhibitor of HIV replication, acting as a chain-terminator of viral DNA by binding to reverse transcriptase; ddI is then metabolized to dideoxyadenosine triphosphate, its putative active metabolite.

Didanosine mechanism of action

Didanosine (ddI) is metabolized intracellularly by a series of cellular enzymes to its active moiety, dideoxyadenosine triphosphate (ddATP), which inhibits the HIV reverse transcriptase enzyme competitively by competing with natural dATP. It also acts as a chain terminator by its incorporation into viral DNA as the lack of a 3′-OH group in the incorporated nucleoside analogue prevents the formation of the 5′ to 3′ phosphodiester linkage essential for DNA chain elongation, and therefore, the viral DNA growth is terminated.

Dosage forms of Didanosine

Videx EC125mg30 EC Capsule$145.33
Videx EC200mg30 EC Capsule$226.46
Videx EC250mg30 EC Capsule$286.61
Videx EC400mg30 EC Capsule$444.00
Didanosine250mg30 EC Capsule$101.00
Didanosine400mg30 EC Capsule$147.00

Prescription Generics


International Brands



2,3-Dideoxyinosine 9-((2R,5S)-5-(Hydroxymethyl)-tetrahydrofuran-2-yl)-1H-purin-6(9H)-one


State of Florida DOH Central Pharmacy

CAS number






Affected organisms

Human Immunodeficiency Virus

Indication of Didanosine

For use, in combination with other antiretroviral agents, in the treatment of HIV-1 infection in adults.

Toxicity of Didanosine

Side effects include pancreatitis, peripheral neuropathy, diarrhea, hyperuricemia and hepatic dysfunction

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