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RX BIN: 015558RX PCN: HTGroup ID: DDN6600Card Holder ID: DDN6600
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2019 Price of Tenuate

$19.5530 tablets/75 mg
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Diethylpropion volume of distribution

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2018 Statistics

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Discount Cards 16,000+

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Clients Benefit 29%

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Total savings $4,735,080

What is Diethylpropion

A appetite depressant considered to produce less central nervous system disturbance than most drugs in this therapeutic category. It is also considered to be among the safest for patients with hypertension. (From AMA Drug Evaluations Annual, 1994, p2290)

Diethylpropion mechanism of action

Diethylpropion is an amphetamine that stimulates neurons to release or maintain high levels of a particular group of neurotransmitters known as catecholamines; these include dopamine and norepinephrine. High levels of these catecholamines tend to suppress hunger signals and appetite. Diethylpropion (through catecholamine elevation) may also indirectly affect leptin levels in the brain. It is theorized that diethylpropion can raise levels of leptin which signal satiety. It is also theorized that increased levels of the catecholamines are partially responsible for halting another chemical messenger known as neuropeptide Y. This peptide initiates eating, decreases energy expenditure, and increases fat storage.

Dosage forms of Diethylpropion

FormRouteStrength
Tabletoral75 mg/1
Tabletoral25 mg/1
Tablet, extended releaseoral75 mg/1

Prescription Generics

false

International Brands

Diethylpropion HCl Controlled-release

Synonyms

(+-)-Diethylpropion ()-diethylpropion

Manufacturers

Preferred Pharmaceuticals, Inc.

CAS number

90-84-6

UNII

Q94YYU22B8

State

solid

Affected organisms

Humans and other mammals

Indication of Diethylpropion

Used in the management of exogenous obesity as a short-term adjunct (a few weeks) in a regimen of weight reduction based on caloric restriction.

Toxicity of Diethylpropion

The reported oral LD sub 50 /sub for mice is 600 mg/kg, for rats is 250 mg/kg and for dogs is 225 mg/kg. Manifestation of acute overdosage include restlessness, tremor, hyperreflexia, rapid respiration, confusion, assaultiveness, hallucinations, and panic states.

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