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RX BIN: 015558
RX PCN: HT
Group ID: DDN6600
Card Holder ID: DDN6600

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2018 Price of Digoxin

Lanoxin 0.25 mg/ml ampul

$1.44

ml

* price without discount in nearest pharmacy. Price may vary.

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Digoxin volume of distribution

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What is Digoxin

A cardiotonic glycoside obtained mainly from Digitalis lanata; it consists of three sugars and the aglycone digoxigenin. Digoxin has positive inotropic and negative chronotropic activity. It is used to control ventricular rate in atrial fibrillation and in the management of congestive heart failure with atrial fibrillation. Its use in congestive heart failure and sinus rhythm is less certain. The margin between toxic and therapeutic doses is small. (From Martindale, The Extra Pharmacopoeia, 30th ed, p666)

Digoxin mechanism of action

Digoxin inhibits the Na-K-ATPase membrane pump, resulting in an increase in intracellular sodium. The sodium calcium exchanger (NCX)in turn tries to extrude the sodium and in so doing, pumps in more calcium. Increased intracellular concentrations of calcium may promote activation of contractile proteins (e.g., actin, myosin). Digoxin also acts on the electrical activity of the heart, increasing the slope of phase 4 depolarization, shortening the action potential duration, and decreasing the maximal diastolic potential.

Dosage forms of Digoxin

DrugDosageQuantityPrice
Lanoxin0.0625mg100 Tablet$55.00
Lanoxin0.125mg100 Tablet$41.00
Lanoxin Solution0.05mg/mL115mL Pediatric Elixir$155.00
Digoxin0.25mg50 Tablet$36.00
Digoxin0.25mg100 Tablet$64.00
Prescription Generics

true

International Brands

Apo-digoxin

Synonyms

12beta-Hydroxydigitoxin 12-hydroxydigitoxin

Manufacturers

Apotex Inc

CAS number

20830-75-5

UNII

73K4184T59

State

solid

Affected organisms

Humans and other mammals

Indication of Digoxin

For the treatment and management of congestive cardiac insufficiency, arrhythmias and heart failure.

Toxicity of Digoxin

Toxicity includes ventricular tachycardia or ventricular fibrillation, or progressive bradyarrhythmias, or heart block. LD sub 50 /sub = 7.8 mg/kg (orally in mice).

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