Save up -80% on Digoxin
|Note: this is a drug discount program, not an insurance plan.|
|RX BIN: 015558||RX PCN: HT||Group ID: DDN6600||Card Holder ID: DDN6600|
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2019 Price of Lanoxin
|price without discount in nearest pharmacy. Price may vary.|
We offer free Lanoxin coupons and discounts that may help you save up to 80% off the retail price in your local pharmacy. Just print your coupon! It’s ready to use and never expire. Present your manufacturer copay card in most local pharmacies to get a discount on Digoxin every time. What are you waiting for? Claim your prescription drug card now!
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Digoxin volume of distribution
Digoxin has a large volume of distribution, due to its high affinity for skeletal and cardiac muscles, intestines and kidney. Digoxin has a distinct distribution phase, which lasts 6-8 hours and thus its disposition is best described by a two-compartment pharmacokinetic model. Adipose tissue is not a reservoir for digoxin; therefore, dosing should be based on the estimated lean body mass. This is often a source of confusion and inappropriate dosing. Binding to plasma proteins, mostly albumin, averages 20 to 30%. Digoxin incompletely distributes across the placental barrier.
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Digoxin
A cardiotonic glycoside obtained mainly from Digitalis lanata; it consists of three sugars and the aglycone digoxigenin. Digoxin has positive inotropic and negative chronotropic activity. It is used to control ventricular rate in atrial fibrillation and in the management of congestive heart failure with atrial fibrillation. Its use in congestive heart failure and sinus rhythm is less certain. The margin between toxic and therapeutic doses is small. (From Martindale, The Extra Pharmacopoeia, 30th ed, p666)
Digoxin mechanism of action
Digoxin inhibits the Na-K-ATPase membrane pump, resulting in an increase in intracellular sodium. The sodium calcium exchanger (NCX)in turn tries to extrude the sodium and in so doing, pumps in more calcium. Increased intracellular concentrations of calcium may promote activation of contractile proteins (e.g., actin, myosin). Digoxin also acts on the electrical activity of the heart, increasing the slope of phase 4 depolarization, shortening the action potential duration, and decreasing the maximal diastolic potential.
Dosage forms of Digoxin
|Lanoxin Solution||0.05mg/mL||115mL Pediatric Elixir||$155.00|
Humans and other mammals
Indication of Digoxin
For the treatment and management of congestive cardiac insufficiency, arrhythmias and heart failure.
Toxicity of Digoxin
Toxicity includes ventricular tachycardia or ventricular fibrillation, or progressive bradyarrhythmias, or heart block. LD sub 50 /sub = 7.8 mg/kg (orally in mice).
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