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RX BIN: 015558
Group ID: DDN6600
Card Holder ID: DDN6600

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2018 Price of Dihydroergotamine

Dihydroergotamine Mesylate 1 mg/ml



* price without discount in nearest pharmacy. Price may vary.

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Dihydroergotamine volume of distribution

* 800 L

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What is Dihydroergotamine

A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders.

Dihydroergotamine mechanism of action

Two theories have been proposed to explain the efficacy of 5-HT sub 1D /sub receptor agonists in migraine: 1) activation of 5-HT sub 1D /sub receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT sub 1D /sub receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.

Dosage forms of Dihydroergotamine

Liquidintramuscular; intravenous; subcutaneous1 mg
Injection, solutionintramuscular; intravenous; subcutaneous1 mg/mL
Spraynasal4 mg/mL
Prescription Generics


International Brands

D.H.E. 45


(2R,4R,7R)-N-((1S,2S,4R,7S)-7-benzyl-2-hydroxy-4-methyl-5,8-dioxo-3-oxa-6,9-diazatricyclo(,6)dodecan-4-yl)-6-methyl-6,11-diazatetracyclo(,7.012,16)hexadeca-1(16),9,12,14-tetraene-4-carboxamide 5′-Benzyl-12′-hydroxy-2′-methyl-3′,6′,18-trioxo-9,10-dihydroergotaman


Valeant Pharmaceuticals North America

CAS number






Affected organisms

Humans and other mammals

Indication of Dihydroergotamine

For the acute treatment of migraine headaches with or without aura and the acute treatment of cluster headache episodes.

Toxicity of Dihydroergotamine

Side effects include abdominal pain, abnormal speech, coma, confusion, convulsions, hallucinations, increase and/or decrease in blood pressure, nausea, numbness, tingling, pain, and a bluish color of your fingersand toes, slowed breathing, vomiting

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