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Price of Dihydroergotamine
Dihydroergotamine Mesylate 1 mg/ml
* price without discount in nearest pharmacy. Price may vary.
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Dihydroergotamine volume of distribution
* 800 L
What is Dihydroergotamine
A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. (PubChem)
Dihydroergotamine mechanism of action
Two theories have been proposed to explain the efficacy of 5-HT sub 1D /sub receptor agonists in migraine: 1) activation of 5-HT sub 1D /sub receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT sub 1D /sub receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.
Dosage forms of Dihydroergotamine
|Liquid||intramuscular; intravenous; subcutaneous||1 mg|
|Injection, solution||intramuscular; intravenous; subcutaneous||1 mg/mL|
Valeant Pharmaceuticals North America
Humans and other mammals
Indication of Dihydroergotamine
For the acute treatment of migraine headaches with or without aura and the acute treatment of cluster headache episodes.
Toxicity of Dihydroergotamine
Side effects include abdominal pain, abnormal speech, coma, confusion, convulsions, hallucinations, increase and/or decrease in blood pressure, nausea, numbness, tingling, pain, and a bluish color of your fingersand toes, slowed breathing, vomiting
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