Save up -80% on Dihydroergotamine
|Note: this is a drug discount program, not an insurance plan.|
|RX BIN: 015558||RX PCN: HT||Group ID: DDN6600||Card Holder ID: DDN6600|
|Pharmacists and Patients support.|
2019 Price of D.H.E. 45
|$1,531.95||1 nasal spray (8 vials) 4mg/ml|
|price without discount in nearest pharmacy. Price may vary.|
We offer free Dihydroergotamine coupons and discounts that may help you save up to 80% off the retail price in your local pharmacy. Just print your coupon! It’s ready to use and never expire. Present your manufacturer copay card in most local pharmacies to get a discount on Dihydroergotamine every time. What are you waiting for? Claim your prescription drug card now!
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Dihydroergotamine volume of distribution
Apparent volume of distribution is about 30 L/kg. The total body clearance is about 1.5 L/min., reflecting mainly the
hepatic clearance. Elimination from the plasma is biphasic with an a-phase of 1.5 hours and a ß-phase of 15 hours.
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Dihydroergotamine
A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders.
Dihydroergotamine mechanism of action
Two theories have been proposed to explain the efficacy of 5-HT sub 1D /sub receptor agonists in migraine: 1) activation of 5-HT sub 1D /sub receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT sub 1D /sub receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.
Dosage forms of Dihydroergotamine
|Liquid||intramuscular; intravenous; subcutaneous||1 mg|
|Injection, solution||intramuscular; intravenous; subcutaneous||1 mg/mL|
Valeant Pharmaceuticals North America
Humans and other mammals
Indication of Dihydroergotamine
For the acute treatment of migraine headaches with or without aura and the acute treatment of cluster headache episodes.
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