Save up -80% on Dihydroergotamine
|Note: this is a drug discount program, not an insurance plan.|
|RX BIN: 015558||RX PCN: HT||Group ID: DDN6600||Card Holder ID: DDN6600|
|Pharmacists and Patients support.|
2019 Price of D.H.E. 45
|$1,531.95||1 nasal spray (8 vials) 4mg/ml|
|Price with discount in nearest pharmacy. Price may vary.|
We offer free Dihydroergotamine coupons and discounts that may help you save up to 80% off the retail price in your local pharmacy. Just print your coupon! It’s ready to use and never expire. Present your manufacturer copay card in most local pharmacies to get a discount on Dihydroergotamine every time. What are you waiting for? Claim your prescription drug card now!
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Dihydroergotamine volume of distribution
Apparent volume of distribution is about 30 L/kg. The total body clearance is about 1.5 L/min., reflecting mainly the
hepatic clearance. Elimination from the plasma is biphasic with an a-phase of 1.5 hours and a ß-phase of 15 hours.
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Dihydroergotamine
A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders.
Dihydroergotamine mechanism of action
Two theories have been proposed to explain the efficacy of 5-HT sub 1D /sub receptor agonists in migraine: 1) activation of 5-HT sub 1D /sub receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT sub 1D /sub receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.
Dosage forms of Dihydroergotamine
|Liquid||intramuscular; intravenous; subcutaneous||1 mg|
|Injection, solution||intramuscular; intravenous; subcutaneous||1 mg/mL|
Valeant Pharmaceuticals North America
Humans and other mammals
Indication of Dihydroergotamine
For the acute treatment of migraine headaches with or without aura and the acute treatment of cluster headache episodes.
Toxicity of Dihydroergotamine
Side effects include abdominal pain, abnormal speech, coma, confusion, convulsions, hallucinations, increase and/or decrease in blood pressure, nausea, numbness, tingling, pain, and a bluish color of your fingersand toes, slowed breathing, vomiting
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