Save up -80% on Dihydrotachysterol
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2018 Price of Dihydrotachysterol
* price without discount in nearest pharmacy. Price may vary.
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Dihydrotachysterol volume of distribution
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Dihydrotachysterol
A vitamin D that can be regarded as a reduction product of vitamin D2.
Dihydrotachysterol mechanism of action
Once hydroxylated to 25-hydroxydihydrotachysterol, the modified drug binds to the vitamin D receptor. The bound form of the vitamin D receptor serves as a transcriptional regulator of bone matrix proteins, inducing the expression of osteocalcin and suppressing synthesis of type I collagen. Vitamin D (when bound to the vitamin D receptor)stimulates the expression of a number of proteins involved in transporting calcium from the lumen of the intestine, across the epithelial cells and into blood. This stimulates intestinal calcium absorption and increases renal phosphate excretion. These are functions that are normally carried out by the parathyroid hormone.
Dosage forms of Dihydrotachysterol
Anti-tetany substance 10 AT 10
Sanofi Synthelabo Canada Inc
Humans and other mammals
Indication of Dihydrotachysterol
Used for the prevention and treatment of rickets or osteomalacia, and to manage hypocalcemia associated with hypoparathyroidism or pseudohypoparathyroidism. Also used for the treatment of vitamin D dependent rickets, rickets or osteomalacia secondary to long-term high dose anticonvulsant therapy, early renal osteodystrophy, osteoporosis (in conjunction with calcium), and hypophosphatemia associated with Fanconi syndrome (with treatment of acidosis).
Toxicity of Dihydrotachysterol
Toxicity associated with dihydrotachysterol is similar to that seen with large doses of vitamin D.
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