Save up -80% on Dimethyl fumarate

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RX BIN: 015558
RX PCN: HT
Group ID: DDN6600
Card Holder ID: DDN6600

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2018 Price of Tecfidera

$388

120mg (14 Capsule)

* price without discount in nearest pharmacy. Price may vary.

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Dimethyl fumarate volume of distribution

In healthy people, MMF has a variable volume of distribution of 53 to 73 litres.

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What is Dimethyl fumarate

Dimethyl fumarate is an anti-inflammatory. It is indicated for multiple sclerosis patients with relapsing forms and is also being investigated for the treatment of psoriasis. The mechanism of action of dimethyl fumarate in multiple sclerosis is not well understood. It is thought to involve dimethyl fumarate degradation to its active metabolite monomethyl fumarate (MMF) then MMF up-regulates the Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) pathway that is activated in response to oxidative stress. Dimethyl fumarate is marketed under the brand name Tecfidera.

Dimethyl fumarate mechanism of action

The mechanism of action of dimethyl fumarate in multiple sclerosis is not well understood. It is thought to involve dimethyl fumarate degradation to its active metabolite monomethyl fumarate (MMF). MMF up-regulates the Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) pathway that is activated in response to oxidative stress. As well MMF is an agonist at the nicotinic acid receptor, but the relevance of this is not known.

Dosage forms of Dimethyl fumarate

DrugDosageQuantityPrice
Tecfidera120mg14 Capsule$388.00
Tecfidera120mg56 Capsule$1,520.00
Tecfidera240mg56 Capsule$2,098.00
Prescription Generics

false

International Brands

Tecfidera

Synonyms

(e)-But-2-enedioic acid dimethyl ester 1,2-Bis(methoxycarbonyl)-trans-ethylene

Manufacturers

Biogen Inc.

CAS number

624-49-7

UNII

FO2303MNI2

State

solid

Affected organisms

Humans and other mammals

Indication of Dimethyl fumarate

Used in multiple sclerosis patients with relapsing forms.

Toxicity of Dimethyl fumarate

The most common side effects observed were nausea, diarrhea, abdominal pain, and flushing.

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