Save up -80% on Dimethyl fumarate
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2018 Price of Tecfidera
120mg (14 Capsule)
* price without discount in nearest pharmacy. Price may vary.
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Dimethyl fumarate volume of distribution
In healthy people, MMF has a variable volume of distribution of 53 to 73 litres.
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Dimethyl fumarate
Dimethyl fumarate is an anti-inflammatory. It is indicated for multiple sclerosis patients with relapsing forms and is also being investigated for the treatment of psoriasis. The mechanism of action of dimethyl fumarate in multiple sclerosis is not well understood. It is thought to involve dimethyl fumarate degradation to its active metabolite monomethyl fumarate (MMF) then MMF up-regulates the Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) pathway that is activated in response to oxidative stress. Dimethyl fumarate is marketed under the brand name Tecfidera.
Dimethyl fumarate mechanism of action
The mechanism of action of dimethyl fumarate in multiple sclerosis is not well understood. It is thought to involve dimethyl fumarate degradation to its active metabolite monomethyl fumarate (MMF). MMF up-regulates the Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) pathway that is activated in response to oxidative stress. As well MMF is an agonist at the nicotinic acid receptor, but the relevance of this is not known.
Dosage forms of Dimethyl fumarate
(e)-But-2-enedioic acid dimethyl ester 1,2-Bis(methoxycarbonyl)-trans-ethylene
Humans and other mammals
Indication of Dimethyl fumarate
Used in multiple sclerosis patients with relapsing forms.
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