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RX BIN: 015558RX PCN: HTGroup ID: DDN6600Card Holder ID: DDN6600
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2019 Price of Rimso-50

$573.051 vial (50ml)/50%
Price with discount in nearest pharmacy. Price may vary.

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Dimethyl sulfoxide volume of distribution

Plasma concentrations of DMSO declined in a biexponential fashion that was well described by the equation Ct = 2.36 exp(-0.449 t) + 1.28 exp(-0.00768 t), indicating a t 1/2 (alpha) of 1.5 min and t 1/2 (beta) of 90 min. DMSO was rapidly and extensively distributed through tissues and was not concentrated in any particular tissue, although at 1 min after injection, the brain contained the lowest concentration of DMSO of any tissue studied.

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What is Dimethyl sulfoxide

A highly polar organic liquid, that is used widely as a chemical solvent. Because of its ability to penetrate biological membranes, it is used as a vehicle for topical application of pharmaceuticals. It is also used to protect tissue during cryopreservation. Dimethyl sulfoxide shows a range of pharmacological activity including analgesia and anti-inflammation.

Dimethyl sulfoxide mechanism of action

The mechanism of dimethyl sulfoxide’s actions is not well understood. Dimethyl sulfoxide has demonstrated antioxidant activity in certain biological settings. For example, the cardiovascular protective effect of dimethyl sulfoxide in copper-deficient rats is thought to occur by an antioxidant mechanism. It is also thought that dimethyl sulfoxide’s possible anti-inflammatory activity is due to antioxidant action.

Dosage forms of Dimethyl sulfoxide

Solution70 %
Irrigantintravesical.54 g/mL
Solutionintravesical500 mg

Prescription Generics


International Brands

Dimethyl Sulfoxide Irrigation USP


(CH3)2SO Dimethyl sulfoxide


Sandoz Canada Incorporated

CAS number






Affected organisms

Humans and other mammals

Indication of Dimethyl sulfoxide

For the symptomatic relief of patients with interstitial cystitis.

Toxicity of Dimethyl sulfoxide

The oral LD sub50 /sub of dimethyl sulfoxide in the dog is greater than 10 gm/kg. It is improbable that this dosage level could be obtained with intravesical instillation of dimethyl sulfoxide in the patient.

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