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RX BIN: 015558
Group ID: DDN6600
Card Holder ID: DDN6600

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2018 Price of Dinoprostone

Prepidil 0.5 mg/3 gm gel



* price without discount in nearest pharmacy. Price may vary.

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Dinoprostone volume of distribution

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What is Dinoprostone

Dinoprostone is a naturally occurring prostaglandin E2 (PGE2). It has important effects in labour. It also stimulates osteoblasts to release factors which stimualtes bone resorption by osteoclasts. As a prescription drug it is used as a vaginal suppository, to prepare the cervix for labour and to induce labour.

Dinoprostone mechanism of action

Dinoprostone administered intravaginally stimulates the myometrium of the gravid uterus to contract in a manner that is similar to the contractions seen in the term uterus during labor, resulting in the evacuation of the products of conception from the uterus. It is believed that dinoprostone exerts its uterine effects via direct myometrial stimulation, but the exact mechanism of action is unkown. Other suggested mechanisms include the regulation of cellular membrane calcium transport and of intracellular concentrations of cyclic 3′,5′-adenosine monophosphate. Dinoprostone also appears to produce local cervical effects including softening, effacement, and dilation. The exact mechanism of action for this effect is also unknown, but it has been suggested that this effect may be associated with collagen degradation caused by secretion of the enzyme collagenase as a partial response to locally administered dinoprostone.

Dosage forms of Dinoprostone

Insertvaginal10 mg
Insert, extended releasevaginal10 mg/1
Insertvaginal10 mg/241mg
Prescription Generics


International Brands



(15S)-Prostaglandin e2 (5Z,11alpha,13e,15S)-11,15-Dihydroxy-9-oxoprosta-5,13-dien-1-oic acid


Ferring Pharmaceuticals Inc.

CAS number






Affected organisms

Humans and other mammals

Indication of Dinoprostone

For the termination of pregnancy during the second trimester (from the 12th through the 20th gestational week as calculated from the first day of the last normal menstrual period), as well as for evacuation of the uterine contents in the management of missed abortion or intrauterine fetal death up to 28 weeks of gestational age as calculated from the first day of the last normal menstrual period. Also used in the management of nonmetastatic gestational trophoblastic disease (benign hydatidiform mole). Other indications include improving the cervical inducibility (cervical “ripening”) in pregnant women at or near term with a medical or obstetrical need for labor induction, and the management of postpartum hemorrhage.

Toxicity of Dinoprostone

Oral, mouse: LD sub 50 /sub = 750 mg/kg; Oral, rat: LD sub 50 /sub = 500 mg/kg.

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