Save up -80% on Diphenhydramine

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RX BIN: 015558RX PCN: HTGroup ID: DDN6600Card Holder ID: DDN6600
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2019 Price of Benadryl

$1.8230 capsules/25mg
price without discount in nearest pharmacy. Price may vary.

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We offer free Benadryl coupons and discounts that may help you save up to 80% off the retail price in your local pharmacy. Just print your coupon! It’s ready to use and never expire. Present your manufacturer copay card in most local pharmacies to get a discount on Diphenhydramine every time. What are you waiting for? Claim your prescription drug card now!

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Diphenhydramine volume of distribution

Following a 50 mg oral dose of diphenhydramine, the volume of distribution is in the range 3.3 – 6.8 l/kg, and it is some 78% bound to plasma proteins. Diphenhydramine undergoes extensive first pass metabolism.

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2018 Statistics

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Clients Benefit 29%


Total savings $4,735,080

What is Diphenhydramine

A histamine H1 antagonist used as an antiemetic, antitussive, for dermatoses and pruritus, for hypersensitivity reactions, as a hypnotic, an antiparkinson, and as an ingredient in common cold preparations. It has some undesired antimuscarinic and sedative effects.

Diphenhydramine mechanism of action

Diphenhydramine competes with free histamine for binding at HA-receptor sites. This antagonizes the effects of histamine on HA-receptors, leading to a reduction of the negative symptoms brought on by histamine HA-receptor binding.

Dosage forms of Diphenhydramine

Nytol Extra Strength50mg20 Tablet$14.13
Sleep Eze25mg20 Caplets$27.50
Sleep Eze Extra Strength50mg10 Caplets$27.00
Unisom25mg20 Tablet$25.00
Benadryl Liquid Elixir12.5mg/5mL120mL Liquid$25.00
Benadryl Itch Spray2%/0.1%59mL Spray$25.00
Benadryl Itch Stick2%/0.1%14mL Stick$25.00

Prescription Generics


International Brands

7 Select Allergy


2-(Benzhydryloxy)-N,N-dimethylethylamine 2-diphenylmethoxy-N,N-demthylethanamine


7 Eleven

CAS number






Affected organisms

Humans and other mammals

Indication of Diphenhydramine

For the treatment of symptoms associated with Vertigo/Meniere’s disease, nausea and vomiting, motion sickness and insect bite.

Toxicity of Diphenhydramine

LD sub 50 /sub =500 mg/kg (orally in rats). Considerable overdosage can lead to myocardial infarction (heart attack), serious ventricular dysrhythmias, coma and death.

RX24 Drugs Disclaimer: consult your healthcare provider before buying a Diphenhydramine on prescription or using an RX manufacturer savings coupon. Content on this page is provided for informational purposes only. Any use of this information is at your own risk.

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What is Benadryl?

Benadryl is an antihistamine that reduces the effects of natural chemical histamine in the body. Histamine can cause symptoms of sneezing, itching, watery eyes and a runny nose. Benadryl is used to treat sneezing, runny nose, watery eyes, hives, skin rashes, itching, and other symptoms of a cold or allergy.

Benadryl is also used to treat motion sickness, to induce sleep, and to treat some symptoms of Parkinson’s disease.

When taking Benadryl, use cautious driving, operating machinery or other dangerous actions. Diphenhydramine may cause dizziness or drowsiness. If you experience dizziness or drowsiness, avoid these activities.

Use alcohol carefully. Alcohol may increase drowsiness and dizziness while taking Benadril. Do not give this medicine to a child under 2 years of age. Always ask a doctor before giving your child a cough or cold. Death can occur from the abuse of cough and cold medicine in very young children.