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RX BIN: 015558RX PCN: HTGroup ID: DDN6600Card Holder ID: DDN6600
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2019 Price of Lomotil

$91.0530 tablets/2.5mg
Price with discount in nearest pharmacy. Price may vary.

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Diphenoxylate volume of distribution

Diphenoxylate is rapidly and extensively metabolized to diphenoxylic acid, an active metabolite. The drug is also metabolized to hydroxydiphenoxylic acid. Diphenoxylate metabolites and their conjugates are slowly excreted, principally in feces via bile; lesser amounts are excreted in urine. Less than 1% is exceted unchanged in urine.

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What is Diphenoxylate

A meperidine congener used as an antidiarrheal, usually in combination with atropine. At high doses, it acts like morphine. Its unesterified metabolite difenoxin has similar properties and is used similarly. It has little or no analgesic activity. This medication is classified as a Schedule V under the Controlled Substances Act by the Food and Drug Administration (FDA) and the DEA in the United States when used in preparations. When diphenoxylate is used alone, it is classified as a Schedule II.

Diphenoxylate mechanism of action

Diphenoxylate is an opiate receptor agonists that stimulate mu receptors in GI to decrease the peristalsis and constrict the sphincters. Diphenoxylate has a direct effect on circular smooth muscle of the bowel, that conceivably results in segmentation and prolongation of gastrointestinal transit time. The clinical antidiarrheal action of diphenoxylate may thus be a consequence of enhanced segmentation that allows increased contact of the intraluminal contents with the intestinal mucosa.

Dosage forms of Diphenoxylate

Dovonex Cream50mcg/g60g Cream$66.00
Dovonex Solution0.005%30mL Solution$35.00
Dovonex Solution0.005%60mL Solution$62.00
Dovonex Ointment50mcg/g90g Ointment$90.00
Dovonex Ointment50mcg/g120g Ointment$109.00

Prescription Generics


International Brands

Diphenoxylate HCl and Atropine Sulfate


1-(3-Cyano-3,3-diphenylpropyl)-4-phenyl-isonipecotic acid ethyl ester 2,2-Diphenyl-4-(4-carbethoxy-4-phenylpiperidino)butyronitrile


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CAS number






Affected organisms

Humans and other mammals

Indication of Diphenoxylate

For as adjunctive therapy in the management of diarrhea

Toxicity of Diphenoxylate

Coma, dry skin and mucous membranes, enlarged pupils of the eyes, extremely high body temperature, flushing, involuntary eyeball movement, lower than normal muscle tone, pinpoint pupils, rapid heartbeat, restlessness, sluggishness, suppressed breathing

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