Save up -80% on Diphenoxylate
|Note: this is a drug discount program, not an insurance plan.|
|RX BIN: 015558||RX PCN: HT||Group ID: DDN6600||Card Holder ID: DDN6600|
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Diphenoxylate volume of distribution
Diphenoxylate is rapidly and extensively metabolized to diphenoxylic acid, an active metabolite. The drug is also metabolized to hydroxydiphenoxylic acid. Diphenoxylate metabolites and their conjugates are slowly excreted, principally in feces via bile; lesser amounts are excreted in urine. Less than 1% is exceted unchanged in urine.
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Diphenoxylate
A meperidine congener used as an antidiarrheal, usually in combination with atropine. At high doses, it acts like morphine. Its unesterified metabolite difenoxin has similar properties and is used similarly. It has little or no analgesic activity. This medication is classified as a Schedule V under the Controlled Substances Act by the Food and Drug Administration (FDA) and the DEA in the United States when used in preparations. When diphenoxylate is used alone, it is classified as a Schedule II.
Diphenoxylate mechanism of action
Diphenoxylate is an opiate receptor agonists that stimulate mu receptors in GI to decrease the peristalsis and constrict the sphincters. Diphenoxylate has a direct effect on circular smooth muscle of the bowel, that conceivably results in segmentation and prolongation of gastrointestinal transit time. The clinical antidiarrheal action of diphenoxylate may thus be a consequence of enhanced segmentation that allows increased contact of the intraluminal contents with the intestinal mucosa.
Dosage forms of Diphenoxylate
|Dovonex Cream||50mcg/g||60g Cream||$66.00|
|Dovonex Solution||0.005%||30mL Solution||$35.00|
|Dovonex Solution||0.005%||60mL Solution||$62.00|
|Dovonex Ointment||50mcg/g||90g Ointment||$90.00|
|Dovonex Ointment||50mcg/g||120g Ointment||$109.00|
Diphenoxylate HCl and Atropine Sulfate
1-(3-Cyano-3,3-diphenylpropyl)-4-phenyl-isonipecotic acid ethyl ester 2,2-Diphenyl-4-(4-carbethoxy-4-phenylpiperidino)butyronitrile
Stat Rx USA
Humans and other mammals
Indication of Diphenoxylate
For as adjunctive therapy in the management of diarrhea
Toxicity of Diphenoxylate
Coma, dry skin and mucous membranes, enlarged pupils of the eyes, extremely high body temperature, flushing, involuntary eyeball movement, lower than normal muscle tone, pinpoint pupils, rapid heartbeat, restlessness, sluggishness, suppressed breathing
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