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Price of Dipivefrin
Propine 0.1% eye drops
* price without discount in nearest pharmacy. Price may vary.
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Dipivefrin volume of distribution
What is Dipivefrin
Dipivefrin is a prodrug of adrenaline, which is used to treat glaucoma. It is available as ophthalmic solution (eye drops).
Dipivefrin mechanism of action
Dipivefrin is a prodrug with little or no pharmacologically activity until it is hydrolyzed into epinephrine inside the human eye. The liberated epinephrine, an adrenergic agonist, appears to exert its action by stimulating . -and/or . sub2 /sub-adrenergic receptors, leading to a decrease in aqueous production and an enhancement of outflow facility. The dipivefrin prodrug delivery system is a more efficient way of delivering the therapeutic effects of epinephrine, with fewer side effects than are associated with conventional epinephrine therapy.
Dosage forms of Dipivefrin
|Drops||ophthalmic; topical||.1 %|
Humans and other mammals
Indication of Dipivefrin
Dipivefrin is a prodrug which is used as initial therapy for the control of intraocular pressure in chronic open-angle glaucoma.
Toxicity of Dipivefrin
Oral LD sub50 /sub in rat is 183 mg/kg.
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