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Price of Disopyramide
Norpace 100 mg capsule
* price without discount in nearest pharmacy. Price may vary.
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Disopyramide volume of distribution
What is Disopyramide
A class I anti-arrhythmic agent (one that interferes directly with the depolarization of the cardiac membrane and thus serves as a membrane-stabilizing agent) with a depressant action on the heart similar to that of guanidine. It also possesses some anticholinergic and local anesthetic properties. (PubChem)
Disopyramide mechanism of action
Disopyramide is a Type 1A antiarrhythmic drug (ie, similar to procainamide and quinidine). It inhibits the fast sodium channels. In animal studies Disopyramide decreases the rate of diastolic depolarization (phase 4) in cells with augmented automaticity, decreases the upstroke velocity (phase 0) and increases the action potential duration of normal cardiac cells, decreases the disparity in refractoriness between infarcted and adjacent normally perfused myocardium, and has no effect on alpha- or beta-adrenergic receptors.
Dosage forms of Disopyramide
|Capsule, gelatin coated||oral||100 mg/1|
Mayne Pharma Inc.
Humans and other mammals
Indication of Disopyramide
For the treatment of documented ventricular arrhythmias, such as sustained ventricular tachycardia, ventricular pre-excitation and cardiac dysrhythmias. It is a Class Ia antiarrhythmic drug.
Toxicity of Disopyramide
LD sub 50 /sub =580 mg/kg in rats
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