Save up -80% on Disulfiram
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2018 Price of Disulfiram
* price without discount in nearest pharmacy. Price may vary.
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Disulfiram volume of distribution
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Disulfiram
A carbamate derivative used as an alcohol deterrent. It is a relatively nontoxic substance when administered alone, but markedly alters the intermediary metabolism of alcohol. When alcohol is ingested after administration of disulfiram, blood acetaldehyde concentrations are increased, followed by flushing, systemic vasodilation, respiratory difficulties, nausea, hypotension, and other symptoms (acetaldehyde syndrome). It acts by inhibiting aldehyde dehydrogenase.
Disulfiram mechanism of action
Disulfiram blocks the oxidation of alcohol at the acetaldehyde stage during alcohol metabolism following disulfiram intake causing an accumulation of acetaldehyde in the blood producing highly unpleasant symptoms. Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase, which acts in the second step of ethanol utilization. In addition, disulfiram competitively binds and inhibits the peripheral benzodiazepine receptor, which may indicate some value in the treatment of the symptoms of alcohol withdrawal, however this activity has not been extensively studied.
Dosage forms of Disulfiram
1,1′-dithiobis(N,N-diethylthioformamide) Antabuse (tn)
Teva Women’s Health, Inc.
Humans and other mammals
Indication of Disulfiram
For the treatment and management of chronic alcoholism
Toxicity of Disulfiram
LDsub50/sub=8.6g/kg (orally in rats). Symptoms of overdose include irritation, slight drowsiness, unpleasant taste, mild GI disturbances, and orthostatic hypotension.
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