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RX BIN: 015558RX PCN: HTGroup ID: DDN6600Card Holder ID: DDN6600
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2019 Price of Antabuse

$39.9330 tablets/250 mg
price without discount in nearest pharmacy. Price may vary.

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Disulfiram volume of distribution

Estimated disulfiram clearance measured 0.35 L/h (coefficient of variation 20%), while volume of distribution stood at 1.6 L and absorption constant at 0.12 h(-1). Disulfiram area under the concentration-time curve rose from 573 mg*h/L with 500 mg daily, to 2845 mg*h/L with 1000 mg, and to 8355 mg*h/L with 2000 mg.

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2018 Statistics

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Discount Cards 16,000+

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Clients Benefit 29%

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Total savings $4,735,080

What is Disulfiram

A carbamate derivative used as an alcohol deterrent. It is a relatively nontoxic substance when administered alone, but markedly alters the intermediary metabolism of alcohol. When alcohol is ingested after administration of disulfiram, blood acetaldehyde concentrations are increased, followed by flushing, systemic vasodilation, respiratory difficulties, nausea, hypotension, and other symptoms (acetaldehyde syndrome). It acts by inhibiting aldehyde dehydrogenase.

Disulfiram mechanism of action

Disulfiram blocks the oxidation of alcohol at the acetaldehyde stage during alcohol metabolism following disulfiram intake causing an accumulation of acetaldehyde in the blood producing highly unpleasant symptoms. Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase, which acts in the second step of ethanol utilization. In addition, disulfiram competitively binds and inhibits the peripheral benzodiazepine receptor, which may indicate some value in the treatment of the symptoms of alcohol withdrawal, however this activity has not been extensively studied.

Dosage forms of Disulfiram

FormRouteStrength
Tabletoral250 mg
Tabletoral500 mg
Tabletoral250 mg/1

Prescription Generics

true

International Brands

Antabuse

Synonyms

1,1′-dithiobis(N,N-diethylthioformamide) Antabuse (tn)

Manufacturers

Teva Women’s Health, Inc.

CAS number

97-77-8

UNII

TR3MLJ1UAI

State

solid

Affected organisms

Humans and other mammals

Indication of Disulfiram

For the treatment and management of chronic alcoholism

Toxicity of Disulfiram

LDsub50/sub=8.6g/kg (orally in rats). Symptoms of overdose include irritation, slight drowsiness, unpleasant taste, mild GI disturbances, and orthostatic hypotension.

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