Save up -80% on Disulfiram
|Note: this is a drug discount program, not an insurance plan.|
|RX BIN: 015558||RX PCN: HT||Group ID: DDN6600||Card Holder ID: DDN6600|
|Pharmacists and Patients support.|
2019 Price of Antabuse
|$39.93||30 tablets/250 mg|
|price without discount in nearest pharmacy. Price may vary.|
We offer free Disulfiram coupons and discounts that may help you save up to 80% off the retail price in your local pharmacy. Just print your coupon! It’s ready to use and never expire. Present your manufacturer copay card in most local pharmacies to get a discount on Disulfiram every time. What are you waiting for? Claim your prescription drug card now!
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Disulfiram volume of distribution
Estimated disulfiram clearance measured 0.35 L/h (coefficient of variation 20%), while volume of distribution stood at 1.6 L and absorption constant at 0.12 h(-1). Disulfiram area under the concentration-time curve rose from 573 mg*h/L with 500 mg daily, to 2845 mg*h/L with 1000 mg, and to 8355 mg*h/L with 2000 mg.
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Disulfiram
A carbamate derivative used as an alcohol deterrent. It is a relatively nontoxic substance when administered alone, but markedly alters the intermediary metabolism of alcohol. When alcohol is ingested after administration of disulfiram, blood acetaldehyde concentrations are increased, followed by flushing, systemic vasodilation, respiratory difficulties, nausea, hypotension, and other symptoms (acetaldehyde syndrome). It acts by inhibiting aldehyde dehydrogenase.
Disulfiram mechanism of action
Disulfiram blocks the oxidation of alcohol at the acetaldehyde stage during alcohol metabolism following disulfiram intake causing an accumulation of acetaldehyde in the blood producing highly unpleasant symptoms. Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase, which acts in the second step of ethanol utilization. In addition, disulfiram competitively binds and inhibits the peripheral benzodiazepine receptor, which may indicate some value in the treatment of the symptoms of alcohol withdrawal, however this activity has not been extensively studied.
Dosage forms of Disulfiram
1,1′-dithiobis(N,N-diethylthioformamide) Antabuse (tn)
Teva Women’s Health, Inc.
Humans and other mammals
Indication of Disulfiram
For the treatment and management of chronic alcoholism
Toxicity of Disulfiram
LDsub50/sub=8.6g/kg (orally in rats). Symptoms of overdose include irritation, slight drowsiness, unpleasant taste, mild GI disturbances, and orthostatic hypotension.
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