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Price of Dofetilide
Tikosyn 500 mcg capsule
* price without discount in nearest pharmacy. Price may vary.
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Dofetilide volume of distribution
* 3 L/kg
What is Dofetilide
Dofetilide is a class III antiarrhythmic agent that is approved by the Food and Drug Administration (FDA) for the maintenance of sinus rhythm in individuals prone to the formation of atrial fibrillation and flutter, and for the chemical cardioversion to sinus rhythm from atrial fibrillation and flutter. (Wikipedia)
Dofetilide mechanism of action
The mechanism of action of Dofetilide is a blockade of the cardiac ion channel carrying the rapid component of the delayed rectifier potassium current, IKr. This inhibition of potassium channels results in a prolongation of action potential duration and the effective refractory period of accessory pathways (both anterograde and retrograde conduction in the accessory pathway).
Dosage forms of Dofetilide
Mayne Pharma Inc.
Humans and other mammals
Indication of Dofetilide
For the maintenance of normal sinus rhythm (delay in time to recurrence of atrial fibrillation/atrial flutter (AF/AFl)) in patients with atrial fibrillation/atrial flutter of greater than one week duration who have been converted to normal sinus rhythm
Toxicity of Dofetilide
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