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RX BIN: 015558
Group ID: DDN6600
Card Holder ID: DDN6600

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2018 Price of Tivicay



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Dolutegravir volume of distribution

Volume of distribution (Vd/F), 50 mg once daily = 17.4 L. The median dolutegravir concentration in the CSF was 18 ng/mL after 2 weeks of treatment.

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What is Dolutegravir

Dolutegravir is indicated for HIV-1 infection for adults and children and adolescents 12 years of age and weighing 40 kg. It is marketed as Tivicay as dolutegravir sodium. 52.6 mg of dolutegravir sodium is equivalent to 50 mg dolutegravir free acid. FDA approved on August 12, 2013.

Dolutegravir mechanism of action

Dolutegravir is an HIV-1 antiviral agent. It inhibits HIV integrase by binding to the active site and blocking the strand transfer step to retroviral DNA integration. This is an essential step of the HIV replication cycle and will result in an inhibition of viral activity. Dolutegravir has a mean EC50 value of 0.5 nM (0.21 ng/mL) to 2.1 nM (0.85 ng/mL) in peripheral blood mononuclear cells (PBMCs) and MT-4 cells.

Dosage forms of Dolutegravir

Tivicay10mg30 tabletes$347.65
Tivicay25mg30 tabletes$854.88
Tivicay50mg90 tabletes$4,904
Prescription Generics


International Brands




Vii V Healthcare Company

CAS number






Affected organisms

Human Immunodeficiency Virus

Indication of Dolutegravir

Dolutegravir is indicated in combination with other antiretroviral agents for the treatment of human immunodeficiency virus type 1 (HIV-1) infection in adults and children aged 12 years and older and weighing at least 40 kg.

Toxicity of Dolutegravir

The most common adverse reactions of moderate to severe intensity and incidence 2% (in those receiving TIVICAY in any one adult trial) are insomnia and headache.

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