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2018 Price of Tivicay
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Dolutegravir volume of distribution
Volume of distribution (Vd/F), 50 mg once daily = 17.4 L. The median dolutegravir concentration in the CSF was 18 ng/mL after 2 weeks of treatment.
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Dolutegravir
Dolutegravir is indicated for HIV-1 infection for adults and children and adolescents 12 years of age and weighing 40 kg. It is marketed as Tivicay as dolutegravir sodium. 52.6 mg of dolutegravir sodium is equivalent to 50 mg dolutegravir free acid. FDA approved on August 12, 2013.
Dolutegravir mechanism of action
Dolutegravir is an HIV-1 antiviral agent. It inhibits HIV integrase by binding to the active site and blocking the strand transfer step to retroviral DNA integration. This is an essential step of the HIV replication cycle and will result in an inhibition of viral activity. Dolutegravir has a mean EC50 value of 0.5 nM (0.21 ng/mL) to 2.1 nM (0.85 ng/mL) in peripheral blood mononuclear cells (PBMCs) and MT-4 cells.
Dosage forms of Dolutegravir
Vii V Healthcare Company
Human Immunodeficiency Virus
Indication of Dolutegravir
Dolutegravir is indicated in combination with other antiretroviral agents for the treatment of human immunodeficiency virus type 1 (HIV-1) infection in adults and children aged 12 years and older and weighing at least 40 kg.
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