Save up -80% on Donepezil
|Note: this is a drug discount program, not an insurance plan.|
|RX BIN: 015558||RX PCN: HT||Group ID: DDN6600||Card Holder ID: DDN6600|
|Pharmacists and Patients support.|
2019 Price of Aricept
|price without discount in nearest pharmacy. Price may vary.|
We offer free Aricept coupons and discounts that may help you save up to 80% off the retail price in your local pharmacy. Just print your coupon! It’s ready to use and never expire. Present your manufacturer copay card in most local pharmacies to get a discount on Donepezil every time. What are you waiting for? Claim your prescription drug card now!
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Donepezil volume of distribution
Steady-state volume of distribution is 12 L/kg. Donepezil is about 96% bound to plasma proteins, mainly to albumins (about 75%) and a1-acid glycoprotein (about 21%) over the concentration range of 2 to 1,000 ng/ml.
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Donepezil
Donepezil (Aricept), is a centrally acting reversible acetyl cholinesterase inhibitor. Its main therapeutic use is in the treatment of Alzheimer’s disease where it is used to increase cortical acetylcholine. Donepezil is postulated to exert its therapeutic effect by enhancing cholinergic function. This is accomplished by increasing the concentration of acetylcholine through reversible inhibition of its hydrolysis by acetylcholinesterase. If this proposed mechanism of action is correct, donepezil’s effect may lessen as the disease process advances and fewer cholinergic neurons remain functionally intact. Donepezil has been tested in other cognitive disorders including Lewy body dementia and Vascular dementia, but it is not currently approved for these indications. Donepezil has also been studied in patients with Mild Cognitive Impairment, schizophrenia, attention deficit disorder, post-coronary bypass cognitive impairment, cognitive impairment associated with multiple sclerosis, and Down syndrome.
Donepezil mechanism of action
Donepezil is a piperidine derivative that is a centerally active, reversible inhibitor of acetylcholinesterase. This drug is structurally unrelated to other anticholinesterase agents. Donepezil’s proposed mechanism of action involves the reversible inhibition of cholinesterases (eg. acetylcholinesterase), which prevents the hydrolysis of acetycholine, and leads to an increased concentration of acetylcholine at cholinergic synapses. Evidence suggests that the anticholinesterase activity of donepezil is relatively specific for acetylcholinesterase in the brain.
Dosage forms of Donepezil
|Aricept Evess||5mg||84 Orally Disintegrating Tablet||$406.00|
|Aricept Evess||10mg||84 Orally Disintegrating Tablet||$456.00|
Accel Pharma Inc
Humans and other mammals
Indication of Donepezil
For the palliative treatment of mild to moderate dementia of the Alzheimer’s type.
Toxicity of Donepezil
Symptoms of overdose include severe nausea, vomiting, salivation, sweating, bradycardia, hypotension, respiratory depression, collapse and convulsions. Increasing muscle weakness is a possibility and may result in death if respiratory muscles are involved.
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