Save up -80% on Donepezil

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RX BIN: 015558
RX PCN: HT
Group ID: DDN6600
Card Holder ID: DDN6600

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2018 Price of Donepezil

Aricept odt 10 mg tablet

$8.03

tablet

* price without discount in nearest pharmacy. Price may vary.

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Donepezil volume of distribution

* 12 L/kg

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What is Donepezil

Donepezil (Aricept), is a centrally acting reversible acetyl cholinesterase inhibitor. Its main therapeutic use is in the treatment of Alzheimer’s disease where it is used to increase cortical acetylcholine. Donepezil is postulated to exert its therapeutic effect by enhancing cholinergic function. This is accomplished by increasing the concentration of acetylcholine through reversible inhibition of its hydrolysis by acetylcholinesterase. If this proposed mechanism of action is correct, donepezil’s effect may lessen as the disease process advances and fewer cholinergic neurons remain functionally intact. Donepezil has been tested in other cognitive disorders including Lewy body dementia and Vascular dementia, but it is not currently approved for these indications. Donepezil has also been studied in patients with Mild Cognitive Impairment, schizophrenia, attention deficit disorder, post-coronary bypass cognitive impairment, cognitive impairment associated with multiple sclerosis, and Down syndrome.

Donepezil mechanism of action

Donepezil is a piperidine derivative that is a centerally active, reversible inhibitor of acetylcholinesterase. This drug is structurally unrelated to other anticholinesterase agents. Donepezil’s proposed mechanism of action involves the reversible inhibition of cholinesterases (eg. acetylcholinesterase), which prevents the hydrolysis of acetycholine, and leads to an increased concentration of acetylcholine at cholinergic synapses. Evidence suggests that the anticholinesterase activity of donepezil is relatively specific for acetylcholinesterase in the brain.

Dosage forms of Donepezil

DrugDosageQuantityPrice
Donepezil5mg100 Tablet$141.00
Donepezil10mg100 Tablet$145.00
Aricept5mg100 Tablet$67.25
Aricept10mg100 Tablet$64.80
Aricept Evess5mg84 Orally Disintegrating Tablet$406.00
Aricept Evess10mg84 Orally Disintegrating Tablet$456.00
Prescription Generics

false

International Brands

Accel-donepezil

Synonyms

Domepezil Donepezil

Manufacturers

Accel Pharma Inc

CAS number

120014-06-4

UNII

8SSC91326P

State

solid

Affected organisms

Humans and other mammals

Indication of Donepezil

For the palliative treatment of mild to moderate dementia of the Alzheimer’s type.

Toxicity of Donepezil

Symptoms of overdose include severe nausea, vomiting, salivation, sweating, bradycardia, hypotension, respiratory depression, collapse and convulsions. Increasing muscle weakness is a possibility and may result in death if respiratory muscles are involved.

RX24 Drugs Disclaimer: before buying a Donepezil on prescription, consult your healthcare provider. Content on this page is provided for informational purposes only. Any use of this information is at your own risk.

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