Save up -80% on Dornase alfa

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RX BIN: 015558RX PCN: HTGroup ID: DDN6600Card Holder ID: DDN6600
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2019 Price of Pulmozyme

$3,423.211 carton (30 ampules) 1mg/ml
price without discount in nearest pharmacy. Price may vary.

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Dornase alfa volume of distribution

In studies in rats and monkeys, the initial volume of distribution is similar to the serum volume. Concentrations in sputum decline rapidly after inhalation.

FormRouteStrength
Solutionrespiratory (inhalation)1 mg/mL
Solutioninhalation1 mg
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2018 Statistics

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Discount Cards 16,000+

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Clients Benefit 29%

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Total savings $4,735,080

What is Dornase alfa

Dornase alfa is a biosynthetic form of human deoxyribunuclease I (DNase I) enzyme. It is produced in genetically modified Chinese hamster ovary (CHO) cells using recombinant DNA technology. The 260-amino acid sequence of dornase alfa is identical to the endogenous human enzyme. Dornase alfa cleaves extracellular DNA to 5?-phosphodinucleotide and 5?-phosphooligonucleotide end products without affecting intracellular DNA. In individuals with cystic fibrosis, extracellular DNA, which is an extremely viscous anion, is released by degenerating leukocytes that accumulate during inflammatory responses to infections. Enzymatic breakdown of this extracellular DNA appears to reduce sputum viscosity and viscoelasticity.

Dornase alfa mechanism of action

Dornase alfa is a biosynthetic form of human DNase I. The enzyme is involved in endonucleolytic cleavage of extracellular DNA to 5?-phosphodinucleotide and 5?-phosphooligonucleotide end products. It has no effect on intracellular DNA. Optimal activity is dependent on the presence of divalent cations such as calcium and magnesium. Extracellular DNA is a viscous anionic polymer and its breakdown appears to improve the viscosity and viscoelasticity of purulent sputum of individuals with CF, thus reducing airflow obstruction. Dornase alfa does not seem to have any effect on non-purulent sputum.

Dosage forms of Dornase alfa

DrugDosageQuantityPrice
Pulmozyme1mg/ml30 ampules$3,523
Pulmozyme1mg/ml60 ampules$7,040
Pulmozyme1mg/ml90 ampules$10,188

Prescription Generics

false

International Brands

Pulmozyme

Synonyms

Deoxyribonuclease (human clone 18-1 protein moiety) Dornase alfa, recombinant

Manufacturers

Genentech, Inc.

CAS number

143831-71-4

UNII

953A26OA1Y

State

liquid

Affected organisms

Humans and other mammals

Indication of Dornase alfa

Used as adjunct therapy in the treatment of cystic fibrosis.

Toxicity of Dornase alfa

Adverse reactions occur at a frequency of 1/1000 and are usually mild and transient in nature. Reported adverse effects include chest pain (pleuritic/non-cardiac), fever, dyspepsia, voice alteration (hoarseness), pharyngitis, dyspnea, laryngitis, rhinitis, decreased lung function, rash, urticaria, and conjunctivitis. There is no evidence of carcinogenic or mutagenic properties. The safety of dornase alfa has not been studied in pregnant women, nursing women and children under the age of 5 years old.

RX24 Drugs Disclaimer: before buying a Dornase alfa on prescription, consult your healthcare provider. Content on this page is provided for informational purposes only. Any use of this information is at your own risk.

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