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RX BIN: 015558
RX PCN: HT
Group ID: DDN6600
Card Holder ID: DDN6600

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2018 Price of Dorzolamide

Trusopt (Preservative-Free) 2 % Solution

$3.93

ml

* price without discount in nearest pharmacy. Price may vary.

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Dorzolamide volume of distribution

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What is Dorzolamide

Dorzolamide is a carbonic anhydrase (CA) inhibitor. It is used in ophthalmic solutions (Trusopt) to lower intraocular pressure (IOP) in open-angle glaucoma and ocular hypertension.

Dorzolamide mechanism of action

Dorzolamide is a sulfonamide and a highly specific carbonic anhydrase II (CA-II) inhibitor, which is the main CA isoenzyme involved in aqueous humor secretion. Inhibition of CA-II in the ciliary processes of the eye decreases aqueous humor secretion, presumably by slowing the formation of bicarbonate ions with subsequent reduction in sodium and fluid transport. Dorzolamide also accumulates in red blood cells as a result of CA-II binding, as CA-II is found predominantly in erythrocytes. However, sufficient CA-II activity remains so that adverse effects due to systemic CA inhibition are not observed.

Dosage forms of Dorzolamide

FormRouteStrength
Solutionophthalmic
Solution/ dropsophthalmic
Solutionophthalmic2.0 %
Prescription Generics

false

International Brands

Act Dorzotimolol

Synonyms

(4S-trans)-4-(ETHYLAMINO)-5,6-dihydro-6-methyl-4H-thieno(2,3-b)thiopyran-2-sulfonamide-7,7-dioxide (4S,6S)-4-Ethylamino-6-methyl-7,7-dioxo-4,5,6,7-tetrahydro-7lambda*6*-thieno(2,3-b)thiopyran-2-sulfonic acid amide

Manufacturers

Actavis Pharma Company

CAS number

120279-96-1

UNII

9JDX055TW1

State

solid

Affected organisms

Humans and other mammals

Indication of Dorzolamide

For the treatment of elevated intraocular pressure in patients with ocular hypertension or open-angle glaucoma. Also used prophylatically for the inhibition of perioperative IOP increase (before neodynium yttrium aluminum garnet laser posterior capsulotomy).

Toxicity of Dorzolamide

Dizziness, headache, shortness of breath, slow heartbeat, severe asthma, cardiac arrest

RX24 Drugs Disclaimer: before buying a Dorzolamide on prescription, consult your healthcare provider. Content on this page is provided for informational purposes only. Any use of this information is at your own risk.

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