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Price of Doxorubicin
Adriamycin 10 mg vial
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Doxorubicin volume of distribution
The distributive half-life is 5 minutes, which suggests that doxorubicin is rapidly taken up by tissue.
Steady state volume of distribution = 809 to 1214 L/m2
What is Doxorubicin
Doxorubicin is a cytotoxic anthracycline antibiotic isolated from cultures of Streptomyces peucetius var. caesius. Doxorubicin binds to nucleic acids, presumably by specific intercalation of the planar anthracycline nucleus with the DNA double helix.
Doxorubicin mechanism of action
Doxorubicin has antimitotic and cytotoxic activity through a number of proposed mechanisms of action: Doxorubicin forms complexes with DNA by intercalation between base pairs, and it inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the ligation-religation reaction that topoisomerase II catalyzes.
Dosage forms of Doxorubicin
|Solution||intravenous; intravesical||2 mg|
|Concentrate for solution for infusion||Intravenous use||2 mg/ml|
West Ward Pharmaceuticals Corp
Humans and other mammals
Indication of Doxorubicin
Doxorubicin is used to produce regression in disseminated neoplastic conditions like acute lymphoblastic leukemia, acute myeloblastic leukemia, Wilms tumor, neuroblastoma, soft tissue and bone sarcomas, breast carcinoma, ovarian carcinoma, transitional cell bladder carcinoma, thyroid carcinoma, gastric carcinoma, Hodgkins disease, malignant lymphoma and bronchogenic carcinoma in which the small cell histologic type is the most responsive compared to other cell types. Doxorubicin is also indicated for use as a component of adjuvant therapy in women with evidence of axillary lymph node involvement following resection of primary breast cancer.
Toxicity of Doxorubicin
LD sub 50 /sub =21800 ug/kg (rat, subcutaneous)
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