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RX BIN: 015558
RX PCN: HT
Group ID: DDN6600
Card Holder ID: DDN6600

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2018 Price of Dronedarone

$

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Dronedarone volume of distribution

When intravenously administered, the volume of distribution is 1400 L.

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What is Dronedarone

Dronedarone is a sinus rhythm controller for management of paroxysmal or persistent atrial fibrillation. Classified as a Class III antiarrhythmic but displays properties of all four Vaughan-Williams classes, dronedarone blocks a multitude of channels (sodium, potassium, calcium), and demonstrates antiadrenergic properties. Chemically, it is a benzofuran derivative. FDA approved on July 1, 2009.

Dronedarone mechanism of action

The antiarrhythmic effect of dronedarone may be due to at least two major actions. It prolongs the duration of action potential and refractory period in myocardial tissue via inhibition of sodium and potassium channels. Via inhibition of calcium channels and blockage of beta1-adrenergic receptors, a decrease in AV conduction and sinus node function can be observed. Dronedarone can also cause an increase in blood pressure by inhibition of alpha1-adrenergic receptors.

Dosage forms of Dronedarone

FormRouteStrength
Film-coated tabletOral use400 mg
Tabletoral400 mg
Tablet, film coatedoral400 mg/1
Prescription Generics

false

International Brands

Multaq

Synonyms

Multaq N-(2-Butyl-3-(4-(3-(dibutylamino)propoxy)benzoyl)-5-benzofuranyl)-methanesulfonamide

Manufacturers

Sanofi Aventis U.S. Llc

CAS number

141626-36-0

UNII

JQZ1L091Y2

State

solid

Affected organisms

Humans and other mammals

Indication of Dronedarone

Management of paroxysmal or persistent atrial fibrillation via restoration of normal sinus rhythm.

Toxicity of Dronedarone

Most common adverse reactions ( 2%) are diarrhea, nausea, abdominal pain, vomiting, and asthenia.

RX24 Drugs Disclaimer: before buying a Dronedarone on prescription, consult your healthcare provider. Content on this page is provided for informational purposes only. Any use of this information is at your own risk.

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