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2018 Price of Dronedarone
* price without discount in nearest pharmacy. Price may vary.
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Dronedarone volume of distribution
When intravenously administered, the volume of distribution is 1400 L.
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Dronedarone
Dronedarone is a sinus rhythm controller for management of paroxysmal or persistent atrial fibrillation. Classified as a Class III antiarrhythmic but displays properties of all four Vaughan-Williams classes, dronedarone blocks a multitude of channels (sodium, potassium, calcium), and demonstrates antiadrenergic properties. Chemically, it is a benzofuran derivative. FDA approved on July 1, 2009.
Dronedarone mechanism of action
The antiarrhythmic effect of dronedarone may be due to at least two major actions. It prolongs the duration of action potential and refractory period in myocardial tissue via inhibition of sodium and potassium channels. Via inhibition of calcium channels and blockage of beta1-adrenergic receptors, a decrease in AV conduction and sinus node function can be observed. Dronedarone can also cause an increase in blood pressure by inhibition of alpha1-adrenergic receptors.
Dosage forms of Dronedarone
|Film-coated tablet||Oral use||400 mg|
|Tablet, film coated||oral||400 mg/1|
Sanofi Aventis U.S. Llc
Humans and other mammals
Indication of Dronedarone
Management of paroxysmal or persistent atrial fibrillation via restoration of normal sinus rhythm.
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