Save up -80% on Dulaglutide
|Note: this is a drug discount program, not an insurance plan.|
|RX BIN: 015558||RX PCN: HT||Group ID: DDN6600||Card Holder ID: DDN6600|
|Pharmacists and Patients support.|
2019 Price of Trulicity
|$632.06||1 carton (4 pens) 0.75mg/0.5ml|
|price without discount in nearest pharmacy. Price may vary.|
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Dulaglutide volume of distribution
After subcutaneous administration of 0.75 mg and 1.5 mg to steady state were approximately 19.2 L (range 14.3 to 26.4 L) and 17.4 L (range 9.3 to 33 L), respectively.
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Dulaglutide
Dulaglutide is a novel glucagon-like peptide-1 agonist (GLP-1) biologic drug consisting of a dipeptidyl peptidase-IV-protected GLP-1 analogue covalently linked to a human IgG4-Fc heavy chain by a small peptide linker. Dulaglutide is indicated in the treatment of type 2 diabetes and can be used once a week. It was approved by the FDA in September 2014. Dulaglutide is manufactured and marketed by Eli Lily under the brand Trulicity . It is not known if dulaglutide can increase the risk of medullary thyroid carcinoma or multiple endocrine neoplasia syndrome type 2, and is thus not recommended for use in populations with a personal or family history of these conditions.
Dulaglutide mechanism of action
Dulaglutide is a human GLP-1 receptor agonist with 90% amino acid sequence homology to endogenous human GLP-1 (7-37). Dulaglutide activates the GLP-1 receptor, a membrane-bound cell-surface receptor coupled to adenylyl cyclase in pancreatic beta cells. Dulaglutide increases intracellular cyclic AMP (cAMP) in beta cells leading to glucose-dependent insulin release. Dulaglutide also decreases glucagon secretion and slows gastric emptying.
Dosage forms of Dulaglutide
Eli Lilly and Company
Humans and other mammals
Indication of Dulaglutide
Indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.
Toxicity of Dulaglutide
-RISK OF THYROID C-CELL TUMORS -Dulaglutide is contraindicated in patients with a personal or family history of MTC or in patients with Multiple Endocrine Neoplasia syndrome type 2 (MEN2). Routine serum calcitonin or thyroid ultrasound monitoring is of uncertain value in patients treated with Dulaglutide.
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What is a Trulicity?
Trulicity is an injectable diabetes medicine that helps control blood sugar levels. Trulicity is used along with diet and exercise to improve blood sugar control in adults with type 2 diabetes. Dulaglutide is usually given after other diabetes medications have been tried without success.
You should not use Trulicity if you have type 2 (MEN 2) multiple endocrine neoplasia syndrome, or a personal or family history of medullary thyroid carcinoma (a type of thyroid cancer). Do not use Trulicity if you are in a state of diabetic ketoacidosis (see your doctor for insulin treatment).
In animal studies, Trulicity caused thyroid tumors or thyroid cancer. It is not known whether these effects will occur in people with regular doses. Ask your doctor about your risk. Call your doctor right away if you have signs of a thyroid tumor, such as a lump or neck lump, problems with swallowing, a hoarse voice, or shortness of breath.