Save up -80% on Duloxetine
|Note: this is a drug discount program, not an insurance plan.|
|RX BIN: 015558||RX PCN: HT||Group ID: DDN6600||Card Holder ID: DDN6600|
|Pharmacists and Patients support.|
2019 Price of Cymbalta
|$9.62||30 capsules/60 mg|
|price without discount in nearest pharmacy. Price may vary.|
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Duloxetine volume of distribution
Administration of duloxetine in the evening rather than the morning causes a three-hour delay in absorption and increases clearance by approximately 33%. The estimated volume of distribution is 1640 L, although there was large variability among subjects (range, 11–50 L/kg).
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Duloxetine
Duloxetine (brand names Cymbalta, Yentreve, and in parts of Europe, Xeristar or Ariclaim) is a drug which primarily targets major depressive disorder (MDD), generalized anxiety disorder (GAD), pain related to diabetic peripheral neuropathy and in some countries stress urinary incontinence (SUI). It is manufactured and marketed by Eli Lilly and Company. Duloxetine has not yet been FDA approved for stress urinary incontinence or for fibromyalgia. Duloxetine is a selective SNRI (selective serotonin-norepinephrine reuptake inhibitor). Duloxetine is a systemic drug therapy which affects the body as a whole. Known also under the code name LY248686, it is a potent dual reuptake inhibitor of serotonin (5-hydroxytryptamine, 5-HT) and norepinephrine (NE), possessing comparable affinities in binding to NE- and 5-HT transporter sites. It is a less potent inhibitor of dopamine reuptake.
Duloxetine mechanism of action
Duloxetine is a potent inhibitor of neuronal serotonin and norepinephrine reuptake and a less potent inhibitor of dopamine reuptake. Duloxetine has no significant affinity for dopaminergic, adrenergic, cholinergic, histaminergic, opioid, glutamate, and GABA receptors. The antidepressant and pain inhibitory actions of duloxetine are believed to be related to its potentiation of serotonergic and noradrenergic activity in the CNS. The mechanism of action of duloxetine in SUI has not been determined, but is thought to be associated with the potentiation of serotonin and norepinephrine activity in the spinal cord, which increases urethral closure forces and thereby reduces involuntary urine loss.
Dosage forms of Duloxetine
|Capsule (delayed release)||oral||30 mg|
|Capsule (delayed release)||oral||60 mg|
|Capsule, delayed release||oral||20 mg/1|
Actavis Pharma Company
Humans and other mammals
Indication of Duloxetine
For the acute and maintenance treatment of major depressive disorder (MDD), as well as acute management of generalized anxiety disorder. Also used for the management of neuropathic pain associated with diabetic peripheral neuropathy, and fibromyalgia. Has been used in the management of moderate to severe stress urinary incontinence (SUI) in women.
Toxicity of Duloxetine
Oral, rat LD sub50 /sub: 491 mg/kg for males and 279 mg/kg for females. Symptoms of overdose include tremors, convulsions, reduced activity, slow pupillary response, intermittent tremors, and rigidity.
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What is Cymbalta?
Cymbalta is a selective antidepressant for serotonin and norepinephrine reuptake inhibitor (SSNRI). The way duloxetine works is still not fully understood. This is believed to have a positive effect on the connection between nerve cells in the central nervous system and / or restores chemical balance in the brain.
Cymbalta is used to treat primary depressive disorder in adults. It is also used to treat general anxiety disorder in adults and children who are at least 7 years old. This drug is also used in adults to treat fibromyalgia (chronic pain) or chronic muscle or joint pain (such as back pain and osteoarthritis pain). Cymbalta is also used to treat pain caused by nerve damage in adults with diabetes (diabetic neuropathy).
You should not use Cymbalta if you have untreated or uncontrolled glaucoma, or if you also take thioridazine. Do not use Cymbalta if you have used a MAO inhibitor in the last 14 days. Dangerous drug interactions can occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, fenelzine, rasagiline, selegiline, tranylcypromine, and others. After you stop taking Cymbalta, you must wait at least 5 days before you start taking an MAOI.
Some young people have thoughts about suicide when they first take an antidepressant. Your doctor will need to check your progress at regular visits while you use Cymbalta. Your family or other caregivers should also be aware of changes in your mood or symptoms.
Report any new or worsening symptoms to your doctor, such as: changes in mood or behavior, anxiety, panic attacks, sleep problems, or if you feel impulsive, irritable, agitated, hostile, aggressive, anxious, hyperactive (mentally or physically), More depressed or thinking about suicide or hurting yourself.