Save up -80% on Dutasteride
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2018 Price of Dutasteride
Avodart 0.5 mg softgel
* price without discount in nearest pharmacy. Price may vary.
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Dutasteride volume of distribution
* 300 to 500 L
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Dutasteride
Dutasteride belongs to a class of drugs called 5-alpha-reductase inhibitors, which block the action of the 5-alpha-reductase enzymes that convert testosterone into dihydrotestosterone (DHT). Finasteride also belongs to this group, but while dutasteride inhibits both isoforms of 5-alpha reductase, finasteride inhibits only one. Even so, a clinical study done by GlaxoSmithKline, the EPICS trial, did not find dutasteride to be more effective than finasteride in treating BPH. (Wikipedia)
Dutasteride mechanism of action
Dutasteride inhibits the conversion of testosterone to 5 alpha-dihydrotestosterone (DHT), which is the androgen primarily responsible for the initial development and subsequent enlargement of the prostate gland. Testosterone is converted to DHT by the enzyme 5 alpha-reductase, which exists as 2 isoforms, type 1 and type 2. Dutasteride is a competitive and specific inhibitor of both type 1 and type 2 5 alpha-reductase isoenzymes, with which it forms a stable enzyme complex. Dissociation from this complex has been evaluated under iin vitro /i and iin vivo /i conditions and is extremely slow. Dutasteride does not bind to the human androgen receptor.
Dosage forms of Dutasteride
Actavis Pharma Company
Humans and other mammals
Indication of Dutasteride
For the treatment of symptomatic benign prostatic hyperplasia (BPH) in men with an enlarged prostate gland to improve symptoms, and reduce the risk of acute urinary retention and the need for surgery.
Toxicity of Dutasteride
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