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RX BIN: 015558RX PCN: HTGroup ID: DDN6600Card Holder ID: DDN6600
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2019 Price of Lufyllin

$137.4130 tablets/200mg
price without discount in nearest pharmacy. Price may vary.

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Dyphylline volume of distribution

Theophylline plasma concentrations decreased triexponentially in 5 of 6 healthy horses after IV infusion of 10 mg of aminophylline/kg of body weight for 16 to 32 minutes. In the 6 horses, total body elimination rate constants were variable, and the half-life of theophylline was 9.7 to 19.3 hours. Clearance was 42.3 to 69.2 ml/hr/kg. The initial distribution phase was rapid (t1/2 approx 3.5 to 4 minutes); a 2nd distribution phase was slower (t1/2 approx 1.5 to 2 hours). Plasma concentrations of theophylline were in the assumed effective range (10 to 20 micrograms/ml) from 15 minutes until 40 minutes after time zero. The mean apparent volume of distribution was 1.02 L/kg.

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2018 Statistics

discount card

Discount Cards 16,000+

benefit

Clients Benefit 29%

savings

Total savings $4,735,080

What is Dyphylline

A theophylline derivative with broncho- and vasodilator properties. It is used in the treatment of asthma, cardiac dyspnea, and bronchitis.

Dyphylline mechanism of action

The bronchodilatory action of dyphylline, as with other xanthines, is thought to be mediated through competitive inhibition of phosphodiesterase with a resulting increase in cyclic AMP producing relaxation of bronchial smooth muscle as well as antagonism of adenosine receptors.

Dosage forms of Dyphylline

FormRouteStrength
Syruporal
Tabletoral200 mg/1
Elixiroral100 mg

Prescription Generics

false

International Brands

Jay-phyl

Synonyms

(+-)-7-(2,3-Dihydroxypropyl)theophylline (+-)-Diprophylline

Manufacturers

Jay Mac Pharmaceuticals Llc

CAS number

479-18-5

UNII

263T0E9RR9

State

solid

Affected organisms

Humans and other mammals

Indication of Dyphylline

For relief of acute bronchial asthma and for reversible bronchospasm associated with chronic bronchitis and emphysema.

Toxicity of Dyphylline

LD sub50 /sub=1954 mg/kg (orally in mice)

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