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RX BIN: 015558RX PCN: HTGroup ID: DDN6600Card Holder ID: DDN6600
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2019 Price of Kalbitor

$29,016.382 cartons (3 vials)/10 mg/ml
Price with discount in nearest pharmacy. Price may vary.

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Ecallantide volume of distribution

The volume of distribution was 26.4 ± 7.8 L in healthy individuals. Intravenous and subcutaneous administration of ecallantide in patients and in healthy subjects resulted in rapid distribution in the vascular compartment.

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2018 Statistics

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Discount Cards 16,000+

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Clients Benefit 29%

savings

Total savings $4,735,080

What is Ecallantide

Ecallantide, a novel Kunitz domain produced by phage display (a powerful method of generating novel binders to potentially therapeutic targets), is a potent and selective inhibitor of plasma kallikrein which demonstrates a useful efficacy/safety ratio in the treatment of acute attacks of HAE (Hereditary Angioedema). On November 27, 2009, ecallantide was approved by the FDA for the treatment of acute attacks of hereditary angioedema for persons over 16 years of age.

Ecallantide mechanism of action

HAE is caused by a mutation of the C1-inhibitor gene. Defective or missing C1-inhibitor permits activation of kallikrein, a protease that is responsible for liberating bradykinin from its precursor kininogen. An excess of bradykinin leads to fluid leakage from blood vessels, causing swelling of tissues typical of HAE. Ecallantide suppresses this pathogenetic mechanism by selectively and reversibly inhibiting the activity of plasma kallikrein.

Dosage forms of Ecallantide

FormRouteStrength
Injection, solutionsubcutaneous10 mg/mL

Prescription Generics

false

International Brands

Kalbitor

Synonyms

Manufacturers

Dyax Corp.

CAS number

460738-38-9

UNII

5Q6TZN2HNM

State

solid

Affected organisms

Humans and other mammals

Indication of Ecallantide

Indicated for the symptomatic treatment of acute attacks of hereditary angioedema (HAE) in patients 12 years of age and older

Toxicity of Ecallantide

While there have been no reports of overdose with ecallantide, patients with hereditary angioedema have received single doses up to 90 mg intravenously without evidence of dose-related toxicity. There are no animal or human studies to assess the carcinogenic or mutagenic potential of ecallantide. In rats receiving subcutaneous doses up to 25 mg/kg/day, there were no observable effects on fertility reproductive performance. An approximate lethal dose was identified as 25 mg/kg intravenously in rats and 5 mg/kg intravenously in rabbits.

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